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    parn-2 CAF1 family ribonuclease [ Caenorhabditis elegans ]

    Gene ID: 174866, updated on 9-Dec-2024

    Summary

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    Official Symbol
    parn-2
    Official Full Name
    CAF1 family ribonuclease
    Primary source
    WormBase:WBGene00013265
    Locus tag
    CELE_Y57A10A.25
    See related
    AllianceGenome:WB:WBGene00013265
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3'-5'-RNA exonuclease activity and snRNA binding activity. Predicted to be involved in snRNA 3'-end processing. Predicted to be active in Cajal body. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 7. Orthologous to human TOE1 (target of EGR1, exonuclease). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See parn-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (12251726..12256628, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene EB domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Trimeric intracellular cation channel type 1B.1 Neighboring gene Failed AXon Connections homolog;GST N-terminal domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expanding the repertoire of deadenylases. Skeparnias I, et al. RNA Biol, 2017 Oct 3. PMID 28267419, Free PMC Article
    2. Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes. Kow RL, et al. Neurobiol Dis, 2021 Jan. PMID 33184027, Free PMC Article
    3. Stage-specific combinations of opposing poly(A) modifying enzymes guide gene expression during early oogenesis. Nousch M, et al. Nucleic Acids Res, 2019 Nov 18. PMID 31511882, Free PMC Article
    4. The Ccr4-Not deadenylase complex constitutes the main poly(A) removal activity in C. elegans. Nousch M, et al. J Cell Sci, 2013 Sep 15. PMID 23843623
    5. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Cajal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CAF1 family ribonuclease
    NP_496602.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      12251726..12256628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064201.6 → NP_496602.1  CAF1 family ribonuclease [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496602.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NA76
      Conserved Domains (1) summary
      pfam04857
      Location:34 → 248
      CAF1; CAF1 family ribonuclease
    Nucleotide Protein
    Heading Accession and Version

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