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    tric-1B.2 Trimeric intracellular cation channel type 1B.2 [ Caenorhabditis elegans ]

    Gene ID: 190342, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tric-1B.2
    Official Full Name
    Trimeric intracellular cation channel type 1B.2
    Primary source
    WormBase:WBGene00013268
    Locus tag
    CELE_Y57A10A.28
    See related
    AllianceGenome:WB:WBGene00013268
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable identical protein binding activity and potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 14. Orthologous to human TMEM38B (transmembrane protein 38B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tric-1B.2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (12275927..12279387, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Armadillo repeat-containing protein 4 Neighboring gene Succinate dehydrogenase assembly factor 2, mitochondrial Neighboring gene Eukaryotic translation initiation factor 4E-5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pore architecture of TRIC channels and insights into their gating mechanism. Yang H, et al. Nature, 2016 Oct 27. PMID 27698420
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Trimeric intracellular cation channel type 1B.2
    NP_496606.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      12275927..12279387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064205.3 → NP_496606.2  Trimeric intracellular cation channel type 1B.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496606.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NA73
      Conserved Domains (1) summary
      pfam05197
      Location:51 → 235
      TRIC; TRIC channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NA73.2

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