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    smut-1 Synthetic MUTator [ Caenorhabditis elegans ]

    Gene ID: 178996, updated on 4-Jan-2025

    Summary

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    Official Symbol
    smut-1
    Official Full Name
    Synthetic MUTator
    Primary source
    WormBase:WBGene00021391
    Locus tag
    CELE_Y38A10A.6
    See related
    AllianceGenome:WB:WBGene00021391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity and nucleic acid binding activity. Is expressed in embryonic cell and germ cell. [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See smut-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (6097105..6099083)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF38 domain-containing protein Neighboring gene N-alpha-acetyltransferase 40 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Calreticulin Neighboring gene DNA-directed DNA polymerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans. Seo M, et al. Proc Natl Acad Sci U S A, 2015 Aug 4. PMID 26195740, Free PMC Article
    2. Disruption of the mutator complex triggers a low penetrance larval arrest phenotype. Rogers AK, et al. MicroPubl Biol, 2020. PMID 32542232, Free PMC Article
    3. Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci. Uebel CJ, et al. PLoS Genet, 2018 Jul. PMID 30036386, Free PMC Article
    4. MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation. Phillips CM, et al. Curr Biol, 2014 Apr 14. PMID 24684932, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation.
      Title: MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Synthetic MUTator
    NP_504574.1
    • Product from WormBase gene class smut;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6097105..6099083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072173.8 → NP_504574.1  Synthetic MUTator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504574.1

      Status: REVIEWED

      Conserved Domains (3) summary
      COG0513
      Location:117 → 520
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00270
      Location:116 → 297
      DEAD; DEAD/DEAH box helicase
      pfam00271
      Location:350 → 469
      Helicase_C; Helicase conserved C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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