U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tag-77 FYVE, RhoGEF and PH domain-containing protein tag-77 [ Caenorhabditis elegans ]

    Gene ID: 177656, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tag-77
    Official Full Name
    FYVE, RhoGEF and PH domain-containing protein tag-77
    Primary source
    WormBase:WBGene00006450
    Locus tag
    CELE_C28C12.10
    See related
    AllianceGenome:WB:WBGene00006450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in hermaphrodite gonad and somatic gonad precursor. Orthologous to human FGD5 (FYVE, RhoGEF and PH domain containing 5) and FGD6 (FYVE, RhoGEF and PH domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See tag-77 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    13
    Sequence:
    Chromosome: IV; NC_003282.8 (8503492..8510548, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene MEiotic SPindle Neighboring gene Transcription termination factor Rho Neighboring gene Polycomb protein mes-6 Neighboring gene Uncharacterized protein Neighboring gene Cyclin-dependent kinases regulatory subunit

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Hayakawa A, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16873553, Free PMC Article
    2. Behavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans. McMullan R, et al. PLoS Pathog, 2012 Feb. PMID 22359503, Free PMC Article
    3. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    FYVE, RhoGEF and PH domain-containing protein tag-77
    NP_001294044.2
    • Confirmed by transcript evidence
    NP_001294045.1
    • Confirmed by transcript evidence
    NP_001294046.1
    • Confirmed by transcript evidence
    NP_001368457.1
    • Confirmed by transcript evidence
    NP_001368458.1
    • Confirmed by transcript evidence
    NP_501455.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8503492..8510548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069054.6 → NP_501455.2  FYVE, RhoGEF and PH domain-containing protein tag-77 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      smart00064
      Location:793 → 860
      FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1
      cd00160
      Location:376 → 570
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13389
      Location:588 → 712
      PH1_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6, N-terminal Pleckstrin Homology (PH) domain

    2. NM_001307115.4 → NP_001294044.2  FYVE, RhoGEF and PH domain-containing protein tag-77 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18284, X5LPV6, X5LV63, X5LX76, X5M5R1, X5M8V6
      Conserved Domains (3) summary
      smart00064
      Location:793 → 860
      FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1
      cd00160
      Location:376 → 570
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13389
      Location:588 → 712
      PH1_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6, N-terminal Pleckstrin Homology (PH) domain

    3. NM_001307116.3 → NP_001294045.1  FYVE, RhoGEF and PH domain-containing protein tag-77 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294045.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5M5R1
      Conserved Domains (3) summary
      smart00064
      Location:678 → 745
      FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1
      cd00160
      Location:261 → 455
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13389
      Location:473 → 597
      PH1_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6, N-terminal Pleckstrin Homology (PH) domain

    4. NM_001307117.3 → NP_001294046.1  FYVE, RhoGEF and PH domain-containing protein tag-77 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294046.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5M8V6
      Conserved Domains (3) summary
      smart00064
      Location:678 → 745
      FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1
      cd00160
      Location:261 → 455
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13389
      Location:473 → 597
      PH1_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6, N-terminal Pleckstrin Homology (PH) domain

    5. NM_001380369.1 → NP_001368458.1  FYVE, RhoGEF and PH domain-containing protein tag-77 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      smart00064
      Location:612 → 679
      FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1
      cd00160
      Location:195 → 389
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13389
      Location:407 → 531
      PH1_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6, N-terminal Pleckstrin Homology (PH) domain

    6. NM_001380370.1 → NP_001368457.1  FYVE, RhoGEF and PH domain-containing protein tag-77 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      smart00064
      Location:612 → 679
      FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1
      cd00160
      Location:195 → 389
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13389
      Location:407 → 531
      PH1_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6, N-terminal Pleckstrin Homology (PH) domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous