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    • Showing Current items.

    zif-1 Zinc finger-interacting factor 1 [ Caenorhabditis elegans ]

    Gene ID: 176274, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zif-1
    Official Full Name
    Zinc finger-interacting factor 1
    Primary source
    WormBase:WBGene00006977
    Locus tag
    CELE_F59B2.6
    See related
    AllianceGenome:WB:WBGene00006977
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in embryo development and ubiquitin-dependent protein catabolic process. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See zif-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (9002779..9004839)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative 26S proteasome regulatory subunit rpn-6.2 Neighboring gene Secreted protein Neighboring gene Ras-related protein rab-6.1 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ZIF-1-mediated degradation of zinc finger proteins in the Caenorhabditis elegans germ line. Schwartz AZA, et al. Genetics, 2023 Nov 1. PMID 37647858, Free PMC Article
    2. emb-4 is a conserved gene required for efficient germline-specific chromatin remodeling during Caenorhabditis elegans embryogenesis. Checchi PM, et al. Genetics, 2006 Dec. PMID 17028322, Free PMC Article
    3. Repurposing an endogenous degradation system for rapid and targeted depletion of C. elegans proteins. Armenti ST, et al. Development, 2014 Dec. PMID 25377555, Free PMC Article
    4. Multiple RNA-binding proteins function combinatorially to control the soma-restricted expression pattern of the E3 ligase subunit ZIF-1. Oldenbroek M, et al. Dev Biol, 2012 Mar 15. PMID 22265679, Free PMC Article
    5. zif-1 translational repression defines a second, mutually exclusive OMA function in germline transcriptional repression. Guven-Ozkan T, et al. Development, 2010 Oct. PMID 20826530, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZIF-1-mediated degradation of zinc finger proteins in the Caenorhabditis elegans germ line.
      Title: ZIF-1-mediated degradation of zinc finger proteins in the Caenorhabditis elegans germ line.
    2. It was shown that ZIF-1 expression in embryos is regulated by five maternally-supplied RNA-binding proteins. POS-1, MEX-3, and SPN-4 function as repressors of ZIF-1 expression, whereas MEX-5 and MEX-6 antagonize this repression.
      Title: Multiple RNA-binding proteins function combinatorially to control the soma-restricted expression pattern of the E3 ligase subunit ZIF-1.
    3. zif-1 encodes the substrate-binding subunit of the E3 ligase for PIE-1 degradation during germline specification.
      Title: zif-1 translational repression defines a second, mutually exclusive OMA function in germline transcriptional repression.
    4. results show that five CCCH finger proteins, components of the Caenorhabditis elegans germ plasm, are targeted for degradation by the novel CCCH-finger-binding protein ZIF-1 [ZIF-1]
      Title: Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Zinc finger-interacting factor 1
    NP_498992.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9002779..9004839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066591.6 → NP_498992.2  Zinc finger-interacting factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498992.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34482
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34482.2

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