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    lact-9 Beta-lactamase-related domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189927, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lact-9
    Official Full Name
    Beta-lactamase-related domain-containing protein
    Primary source
    WormBase:WBGene00012890
    Locus tag
    CELE_Y45F10D.11
    See related
    AllianceGenome:WB:WBGene00012890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in proteolysis and regulation of lipid metabolic process. Predicted to be active in mitochondrion. Orthologous to human LACTB (lactamase beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lact-9 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (13782383..13785645, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Large ribosomal subunit protein eL18 Neighboring gene Putative polypeptide N-acetylgalactosaminyltransferase 10;Ricin B lectin domain-containing protein Neighboring gene NIF system FeS cluster assembly NifU N-terminal domain-containing protein Neighboring gene Integrin Cytoplasmic domain-Associated Protein homolog Neighboring gene Spindle assembly abnormal protein 6 Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene Abnormal cell migration protein 18-like fibronectin type I domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain. Smith TS, et al. Genomics, 2001 Nov. PMID 11707067
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Beta-lactamase-related domain-containing protein
    NP_001041033.1
    • Confirmed by transcript evidence
    NP_001041034.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13782383..13785645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047568.4 → NP_001041033.1  Beta-lactamase-related domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041033.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62481
      Conserved Domains (1) summary
      pfam00144
      Location:44 → 406
      Beta-lactamase

    2. NM_001047569.3 → NP_001041034.1  Beta-lactamase-related domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041034.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2HQM1
      Conserved Domains (1) summary
      cl21491
      Location:1 → 166
      Transpeptidase; Penicillin binding protein transpeptidase domain
    Nucleotide Protein
    Heading Accession and Version

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