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    faxc-1 Failed AXon Connections homolog;GST N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174868, updated on 9-Dec-2024

    Summary

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    Official Symbol
    faxc-1
    Official Full Name
    Failed AXon Connections homolog;GST N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00013266
    Locus tag
    CELE_Y57A10A.26
    See related
    AllianceGenome:WB:WBGene00013266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be active in cytoplasm. Orthologous to human FAXC (failed axon connections homolog, metaxin like GST domain containing). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See faxc-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (12264192..12266105)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene CAF1 family ribonuclease Neighboring gene Trimeric intracellular cation channel type 1B.1 Neighboring gene ncRNA Neighboring gene Armadillo repeat-containing protein 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SPD-3 is required for spindle alignment in Caenorhabditis elegans embryos and localizes to mitochondria. Dinkelmann MV, et al. Genetics, 2007 Nov. PMID 17947426, Free PMC Article
    2. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    3. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    4. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Failed AXon Connections homolog;GST N-terminal domain-containing protein
    NP_001417608.1
    • Product from WormBase gene class faxc;
      Confirmed by transcript evidence
    NP_496604.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      12264192..12266105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064203.5 → NP_496604.1  GST N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496604.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NA74
      Conserved Domains (2) summary
      cd03193
      Location:176 → 246
      GST_C_Metaxin; C-terminal, alpha helical domain of Metaxin and related proteins
      cd03080
      Location:15 → 89
      GST_N_Metaxin_like; GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It ...

    2. NM_001430678.1 → NP_001417608.1  Failed AXon Connections homolog [Caenorhabditis elegans]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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