rimb-1 Variant SH3 domain protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rimb-1
Official Full Name: Variant SH3 domain protein
Primary source: WormBase:WBGene00006513
Locus tag: CELE_Y39A3CL.2
See related: AllianceGenome:WB:WBGene00006513
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in neuromuscular synaptic transmission. Predicted to be located in synapse. Is expressed in nervous system. Human ortholog(s) of this gene implicated in dystonia 22, adult-onset and dystonia 22, juvenile-onset. Orthologous to human RIMBP2 (RIMS binding protein 2) and TSPOAP1 (TSPO associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rimb-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 20

Sequence:: Chromosome: III; NC_003281.10 (1788333..1807147)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits.
Title: RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits.
C. elegans Clarinet/CLA-1 recruits RIMB-1/RIM-binding protein and UNC-13 to orchestrate presynaptic neurotransmitter release.
Title: C. elegans Clarinet/CLA-1 recruits RIMB-1/RIM-binding protein and UNC-13 to orchestrate presynaptic neurotransmitter release.
RIMB-1/RIM-Binding Protein and UNC-10/RIM Redundantly Regulate Presynaptic Localization of the Voltage-Gated Calcium Channel in Caenorhabditis elegans.
Title: RIMB-1/RIM-Binding Protein and UNC-10/RIM Redundantly Regulate Presynaptic Localization of the Voltage-Gated Calcium Channel in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y39A3C_85.d (e-PCR)
- UniSTS:324297

Y39A3C_85.b (e-PCR)
- UniSTS:322782

Y39A3C_85.e (e-PCR)
- UniSTS:322783

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in neuromuscular synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Variant SH3 domain protein

NP_001380064.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

1788333..1807147

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001393286.1 → NP_001380064.1 Variant SH3 domain protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A650C2J5, Q9N415

Conserved Domains (4) summary

cd12012
Location:763 → 823

SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12013
Location:1099 → 1160

SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12014
Location:63 → 124

SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

pfam00041
Location:285 → 348

fn3; Fibronectin type III domain