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    cng-2 Cyclic nucleotide-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190732, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cng-2
    Official Full Name
    Cyclic nucleotide-binding domain-containing protein
    Primary source
    WormBase:WBGene00022295
    Locus tag
    CELE_Y76B12C.1
    See related
    AllianceGenome:WB:WBGene00022295
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cGMP binding activity; intracellularly cAMP-activated cation channel activity; and intracellularly cGMP-activated cation channel activity. Predicted to be involved in monoatomic cation transmembrane transport. Located in neuronal cell body. Is expressed in amphid neurons. Human ortholog(s) of this gene implicated in achromatopsia 2; color blindness; retinitis pigmentosa; and retinitis pigmentosa 49. Orthologous to several human genes including CNGA1 (cyclic nucleotide gated channel subunit alpha 1); CNGA2 (cyclic nucleotide gated channel subunit alpha 2); and CNGA3 (cyclic nucleotide gated channel subunit alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cng-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    14
    Sequence:
    Chromosome: IV; NC_003282.8 (2037191..2043549)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cleavage/polyadenylation specificity factor A subunit C-terminal domain-containing protein;MMS1_N domain-containing protein;putative cleavage and polyadenylation specificity factor subunit 1 Neighboring gene NUP50 domain-containing protein Neighboring gene ncRNA Neighboring gene Ovule protein;Protein shisa-9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Immediate activation of chemosensory neuron gene expression by bacterial metabolites is selectively induced by distinct cyclic GMP-dependent pathways in Caenorhabditis elegans. Park J, et al. PLoS Genet, 2020 Aug. PMID 32776934, Free PMC Article
    2. A new putative cyclic nucleotide-gated channel gene, cng-3, is critical for thermotolerance in Caenorhabditis elegans. Cho SW, et al. Biochem Biophys Res Commun, 2004 Dec 10. PMID 15530424
    3. Cell- and subunit-specific mechanisms of CNG channel ciliary trafficking and localization in C. elegans. Wojtyniak M, et al. J Cell Sci, 2013 Oct 1. PMID 23886944, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cGMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cAMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cGMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of intracellular cyclic nucleotide activated cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cyclic nucleotide-binding domain-containing protein
    NP_001294580.1
    • Confirmed by transcript evidence
    NP_001343690.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2037191..2043549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356909.3 → NP_001343690.1  Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4C1
      Conserved Domains (3) summary
      PLN03192
      Location:457 → 713
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:594 → 711
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:232 → 407
      Ion_trans; Ion transport protein

    2. NM_001307651.3 → NP_001294580.1  Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294580.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PCB8
      Conserved Domains (1) summary
      cd00038
      Location:3 → 104
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    Nucleotide Protein
    Heading Accession and Version

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