rabx-5 Rab5 GDP/GTP exchange factor [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rabx-5
Official Full Name: Rab5 GDP/GTP exchange factor
Primary source: WormBase:WBGene00012644
Locus tag: CELE_Y39A1A.5
See related: AllianceGenome:WB:WBGene00012644
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in endosomal vesicle fusion and molting cycle. Located in early endosome. Is expressed in several structures, including coelomocyte; distal tip cell; neurons; ventral nerve cord; and vulva. Orthologous to human RABGEF1 (RAB guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See rabx-5 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (10605349..10614930)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that rabx-5 regulation of RAB-5 compartments is important for maintaining proper synaptic function throughout the lifetime.
Title: Rabx-5 regulates RAB-5 early endosomal compartments and synaptic vesicles in C. elegans.
Up-regulated in NF-kappaB activation in mature dendritic cells(DC) from allogeneic liver grafts undergoing acute rejection. Limits NF-kappaB activation and maturation of DCs. Inhibits acute rejection and induces acceptance of liver graft.
Title: NF-kappaB activation and zinc finger protein A20 expression in mature dendritic cells derived from liver allografts undergoing acute rejection.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y39A1A.2 (e-PCR)
- UniSTS:305741

Y39A1A.4 (e-PCR)
- UniSTS:320160

Y39A1A.5 (e-PCR)
- UniSTS:318907

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endosomal vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in molting cycle, collagen and cuticulin-based cuticle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Rab5 GDP/GTP exchange factor

NP_001360492.1

Confirmed by transcript evidence

NP_001379324.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10605349..10614930

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392197.1 → NP_001379324.1 Rab5 GDP/GTP exchange factor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8I100

Conserved Domains (3) summary

pfam02204
Location:256 → 358

VPS9; Vacuolar sorting protein 9 (VPS9) domain

pfam01754
Location:21 → 43

zf-A20; A20-like zinc finger

pfam18151
Location:144 → 209

DUF5601; Domain of unknown function (DUF5601)
NM_001372654.2 → NP_001360492.1 Rab5 GDP/GTP exchange factor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WY48

Conserved Domains (3) summary

pfam01754
Location:21 → 44

zf-A20; A20-like zinc finger

pfam02204
Location:259 → 361

VPS9; Vacuolar sorting protein 9 (VPS9) domain

pfam18151
Location:147 → 212

DUF5601; Domain of unknown function (DUF5601)