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    trp-4 Ion transport domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190574, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trp-4
    Official Full Name
    Ion transport domain-containing protein
    Primary source
    WormBase:WBGene00006616
    Locus tag
    CELE_Y71A12B.4
    See related
    AllianceGenome:WB:WBGene00006616
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to be active in membrane. Is expressed in ciliated neurons; dopaminergic neurons; dorsal-rectal ganglion neurons; head mesodermal cell; and rectum. Orthologous to human ANKRD28 (ankyrin repeat domain 28) and ANKRD44 (ankyrin repeat domain 44). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See trp-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    24
    Sequence:
    Chromosome: I; NC_003279.8 (13899085..13914008)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene PAN-3 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans. Ibsen S, et al. Nat Commun, 2015 Sep 15. PMID 26372413, Free PMC Article
    2. In touch - the molecular basis of mechanosensory transduction. Kang L, et al. Biochem (Lond), 2011 Dec. PMID 25598582, Free PMC Article
    3. Evolutionarily conserved mechanisms in calcium handling may underlie intrinsic sensitivity to dopaminergic neuron death. Taub DG. J Neurosci, 2014 Aug 13. PMID 25122882, Free PMC Article
    4. C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel. Kang L, et al. Neuron, 2010 Aug 12. PMID 20696377, Free PMC Article
    5. Mechano-gated channels in C. elegans. Al-Sheikh U, et al. J Neurogenet, 2020 Sep-Dec. PMID 33325279

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuron-specific misexpression of TRP-4, the pore-forming subunit of a mechanotransduction channel, sensitizes neurons to ultrasound stimulus, resulting in behavioural outputs.
      Title: Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans.
    2. TRP-4 functions as an essential pore-forming subunit of a native mechanotransduction channel.
      Title: C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel.
    3. TRP-4 acts in a single neuron, DVA, to mediate its function in proprioception, and that the activity of DVA can be stimulated by body stretch
      Title: A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ion transport domain-containing protein
    NP_493429.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13899085..13914008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061028.3 → NP_493429.2  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493429.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GRV5
      Conserved Domains (5) summary
      PHA02876
      Location:712 → 1040
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:430 → 756
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:280 → 515
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      TIGR00870
      Location:1209 → 1879
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:886 → 917
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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