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    nova-1 K Homology domain-containing protein;KH domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180183, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nova-1
    Official Full Name
    K Homology domain-containing protein;KH domain-containing protein
    Primary source
    WormBase:WBGene00013347
    Locus tag
    CELE_Y59A8B.10
    See related
    AllianceGenome:WB:WBGene00013347
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in cytoplasm and nucleus. Orthologous to several human genes including NOVA1 (NOVA alternative splicing regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nova-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (18070004..18081957, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene EB1 C-terminal domain-containing protein Neighboring gene Gamma-soluble NSF attachment protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene MATH domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo. Berends CW, et al. Mol Biol Cell, 2013 Jul. PMID 23699393, Free PMC Article
    2. Robust regulatory architecture of pan-neuronal gene expression. Leyva-Díaz E, et al. Curr Biol, 2022 Apr 25. PMID 35259341, Free PMC Article
    3. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
    4. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article
    5. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    K Homology domain-containing protein;KH domain-containing protein
    NP_001256769.1
    • Confirmed by transcript evidence
    NP_001256770.1
    • Confirmed by transcript evidence
    NP_001256771.1
    • Confirmed by transcript evidence
    NP_001360614.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      18070004..18081957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269840.2 → NP_001256769.1  K Homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256769.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GRY9
      Conserved Domains (1) summary
      cd02396
      Location:43 → 109
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

    2. NM_001373184.1 → NP_001360614.1  K Homology domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0ILI5
      Conserved Domains (1) summary
      cd02396
      Location:47 → 113
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

    3. NM_001269841.3 → NP_001256770.1  K Homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256770.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0R7K7
      Conserved Domains (1) summary
      cd02396
      Location:34 → 103
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

    4. NM_001269842.3 → NP_001256771.1  KH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256771.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0R7K8
    Nucleotide Protein
    Heading Accession and Version

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