exc-6 Excretory canal abnormal protein 6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: exc-6
Official Full Name: Excretory canal abnormal protein 6
Primary source: WormBase:WBGene00019030
Locus tag: CELE_F58B6.2
See related: AllianceGenome:WB:WBGene00019030
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin binding activity. Involved in several processes, including epithelial cell development; regulation of microtubule polymerization; and regulation of tube size. Part of filamentous actin. Is expressed in several structures, including excretory cell; pharynx; rectal gland cell; reproductive system; and tail neurons. Orthologous to human FHDC1 (FH2 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See exc-6 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 11

Sequence:: Chromosome: III; NC_003281.10 (1103208..1111944)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EXC-6 plays a role directly in the spermatheca, perhaps by modulating the ability of the spermatheca wall to rapidly accommodate an incoming oocyte, while FHOD-1 may play an indirect role relating to its known importance in the growth and function of the egg-laying muscles
Title: INF2- and FHOD-related formins promote ovulation in the somatic gonad of C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F58B6.2 (e-PCR)
- UniSTS:306827

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube size	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of filamentous actin	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Excretory canal abnormal protein 6

NP_497334.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

1103208..1111944

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064933.5 → NP_497334.2 Excretory canal abnormal protein 6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497334.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9TYU9

Conserved Domains (1) summary

pfam02181
Location:140 → 487

FH2; Formin Homology 2 Domain