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    galt-1 Beta-1,4-galactosyltransferase galt-1 [ Caenorhabditis elegans ]

    Gene ID: 187430, updated on 9-Dec-2024

    Summary

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    Official Symbol
    galt-1
    Official Full Name
    Beta-1,4-galactosyltransferase galt-1
    Primary source
    WormBase:WBGene00019763
    Locus tag
    CELE_M03F8.4
    See related
    AllianceGenome:WB:WBGene00019763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity. Involved in N-glycan processing and protein galactosylation. Predicted to be located in Golgi cisterna membrane. Predicted to be active in cytoplasm. Is expressed in coelomocyte and intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See galt-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (5930905..5933435)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Glycosyltransferase family 92 protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene TPR_REGION domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Array-assisted characterization of a fucosyltransferase required for the biosynthesis of complex core modifications of nematode N-glycans. Yan 闫石 S, et al. J Biol Chem, 2013 Jul 19. PMID 23754284, Free PMC Article
    2. Caenorhabditis elegans galectins LEC-6 and LEC-10 interact with similar glycoconjugates in the intestine. Maduzia LL, et al. J Biol Chem, 2011 Feb 11. PMID 21115491, Free PMC Article
    3. Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2. Butschi A, et al. PLoS Pathog, 2010 Jan. PMID 20062796, Free PMC Article
    4. Molecular basis for galactosylation of core fucose residues in invertebrates: identification of caenorhabditis elegans N-glycan core alpha1,6-fucoside beta1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family. Titz A, et al. J Biol Chem, 2009 Dec 25. PMID 19858195, Free PMC Article
    5. Isolation and molecular identification of nematode surface mutants with resistance to bacterial pathogens. O'Rourke D, et al. G3 (Bethesda), 2023 May 2. PMID 36911920, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables UDP-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein galactosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Beta-1,4-galactosyltransferase galt-1
    NP_504545.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5930905..5933435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072144.8 → NP_504545.2  Beta-1,4-galactosyltransferase galt-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504545.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G4RVA7, O16374
      Conserved Domains (1) summary
      cl11394
      Location:188 → 393
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16374.4

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