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    Y56A3A.2 Membrane-bound transcription factor site-2 protease [ Caenorhabditis elegans ]

    Gene ID: 176616, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y56A3A.2
    Official Full Name
    Membrane-bound transcription factor site-2 protease
    Primary source
    WormBase:WBGene00013225
    Locus tag
    CELE_Y56A3A.2
    See related
    AllianceGenome:WB:WBGene00013225
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein intracellular domain proteolysis and regulation of response to endoplasmic reticulum stress. Predicted to be located in membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in X-linked keratosis follicularis spinulosa decalvans; X-linked mutilating palmoplantar keratoderma with periorificial keratotic plaques; ichthyosis follicularis-alopecia-photophobia syndrome 1; and osteogenesis imperfecta type 19. Orthologous to human MBTPS2 (membrane bound transcription factor peptidase, site 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y56A3A.2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (11849452..11862249, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene NOT2/NOT3/NOT5 C-terminal domain-containing protein;Not3 domain-containing protein Neighboring gene L-dopachrome isomerase Neighboring gene Transcription initiation factor TFIID subunit 12 Neighboring gene WH2 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane protein intracellular domain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Membrane-bound transcription factor site-2 protease
    NP_499537.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11849452..11862249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067136.7 → NP_499537.2  Membrane-bound transcription factor site-2 protease [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499537.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U227
      Conserved Domains (1) summary
      cl10020
      Location:185 → 282
      S2P-M50; Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic ...
    Nucleotide Protein
    Heading Accession and Version

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