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    tmem-39 uncharacterized protein [ Caenorhabditis elegans ]

    Gene ID: 172060, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tmem-39
    Official Full Name
    uncharacterized protein
    Primary source
    WormBase:WBGene00017003
    Locus tag
    CELE_D1007.5
    See related
    AllianceGenome:WB:WBGene00017003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be active in membrane. Is expressed in hypodermis; intestine; and nervous system. Orthologous to human TMEM39A (transmembrane protein 39A) and TMEM39B (transmembrane protein 39B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tmem-39 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (4580708..4583810, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene AD domain-containing protein Neighboring gene Plectin/eS10 N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved autoimmune-disease risk gene TMEM39A regulates lysosome dynamics. Luo S, et al. Proc Natl Acad Sci U S A, 2021 Feb 9. PMID 33531362, Free PMC Article
    2. Acquired stress resilience through bacteria-to-nematode interdomain horizontal gene transfer. Pandey T, et al. EMBO J, 2023 Dec 11. PMID 37953666, Free PMC Article
    3. The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response. Zhang Z, et al. PLoS Genet, 2021 Feb. PMID 33524011, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_001021071.1
    • Partially confirmed by transcript evidence;
      Product from WormBase gene class tmem; TMEM (human TransMEMbrane protein) homolog
    NP_001021072.1
    • Partially confirmed by transcript evidence;
      Product from WormBase gene class tmem; TMEM (human TransMEMbrane protein) homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4580708..4583810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025900.5 → NP_001021071.1  uncharacterized protein CELE_D1007.5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021071.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01870
      Conserved Domains (1) summary
      pfam10271
      Location:17 → 461
      Tmp39; Putative transmembrane protein

    2. NM_001025901.6 → NP_001021072.1  uncharacterized protein CELE_D1007.5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021072.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZB3
      Conserved Domains (1) summary
      pfam10271
      Location:17 → 395
      Tmp39; Putative transmembrane protein
    Nucleotide Protein
    Heading Accession and Version

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