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    zipt-2.3 Zinc transporter ZIP3 [ Caenorhabditis elegans ]

    Gene ID: 190293, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zipt-2.3
    Official Full Name
    Zinc transporter ZIP3
    Primary source
    WormBase:WBGene00013207
    Locus tag
    CELE_Y54G9A.4
    See related
    AllianceGenome:WB:WBGene00013207
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in zinc ion transmembrane transport. Located in gut granule. Is expressed in intestine. Orthologous to human SLC39A1 (solute carrier family 39 member 1) and SLC39A2 (solute carrier family 39 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See zipt-2.3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (13712906..13715879, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Potassium voltage-gated channel subfamily KQT member 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class E (Epsilon)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lysosome-related organelles contain an expansion compartment that mediates delivery of zinc transporters to promote homeostasis. Mendoza AD, et al. Proc Natl Acad Sci U S A, 2024 Feb 13. PMID 38330011, Free PMC Article
    2. A pathway for low zinc homeostasis that is conserved in animals and acts in parallel to the pathway for high zinc homeostasis. Dietrich N, et al. Nucleic Acids Res, 2017 Nov 16. PMID 28977437, Free PMC Article
    3. A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis. Chapman EM, et al. Nat Commun, 2019 Apr 17. PMID 30996251, Free PMC Article
    4. The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity. Bailly AP, et al. Cell Rep, 2019 Oct 1. PMID 31577950, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in gut granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Zinc transporter ZIP3
    NP_496876.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13712906..13715879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064475.5 → NP_496876.1  Zinc transporter ZIP3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496876.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWH3
      Conserved Domains (1) summary
      pfam02535
      Location:5 → 315
      Zip; ZIP Zinc transporter
    Nucleotide Protein
    Heading Accession and Version

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