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    dao-5 Nucleolar protein dao-5 [ Caenorhabditis elegans ]

    Gene ID: 266845, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dao-5
    Official Full Name
    Nucleolar protein dao-5
    Primary source
    WormBase:WBGene00000931
    Locus tag
    CELE_C25A1.10
    See related
    AllianceGenome:WB:WBGene00000931
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase I core binding activity and rDNA binding activity. Involved in several processes, including determination of adult lifespan; insulin receptor signaling pathway; and nucleolar large rRNA transcription by RNA polymerase I. Located in nucleolus and nucleoplasm. Is expressed in several structures, including germ line; germline precursor cell; gonadal sheath cell; nervous system; and somatic cell. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dao-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (10187546..10190896, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Proteasome assembly chaperone 3 Neighboring gene isoleucine--tRNA ligase Neighboring gene C-type lectin domain-containing protein 87 Neighboring gene Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1 Neighboring gene AB hydrolase-1 domain-containing protein;Abhydrolase domain-containing protein lid-1 Neighboring gene Large ribosomal subunit protein mL43 Neighboring gene Aryl hydrocarbon receptor nuclear translocator homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans. Lee CC, et al. Cell Death Dis, 2014 Apr 10. PMID 24722283, Free PMC Article
    2. Nucleologenesis in the Caenorhabditis elegans embryo. Korčeková D, et al. PLoS One, 2012. PMID 22768349, Free PMC Article
    3. Aging disrupts spatiotemporal regulation of germline stem cells and niche integrity. Urman MA, et al. Biol Open, 2024 Jan 15. PMID 38156664, Free PMC Article
    4. Notch-dependent DNA cis-regulatory elements and their dose-dependent control of C. elegans stem cell self-renewal. Lynch TR, et al. Development, 2022 Apr 1. PMID 35394007, Free PMC Article
    5. Expansion microscopy of C. elegans. Yu CJ, et al. Elife, 2020 May 1. PMID 32356725, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A null dao-5 mutant ok542 with a semi-infertile phenotype showed a delay in gonadogenesis, as well as a higher incidence of germline apoptosis.[dao-5]
      Title: Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA polymerase I core binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rDNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dauer larval development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nucleolar large rRNA transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nucleolar protein dao-5
    NP_001021004.1
    • Confirmed by transcript evidence
    NP_001021005.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10187546..10190896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025833.10 → NP_001021004.1  Nucleolar protein dao-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021004.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q564W7, Q9XVS4
      Conserved Domains (4) summary
      pfam05022
      Location:897 → 945
      SRP40_C; SRP40, C-terminal domain
      cl26128
      Location:196 → 321
      tRNA-synt_1g; tRNA synthetases class I (M)
      cl26386
      Location:389 → 606
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
      cl26464
      Location:445 → 886
      Atrophin-1; Atrophin-1 family

    2. NM_001025834.6 → NP_001021005.1  Nucleolar protein dao-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021005.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q564W7
      Conserved Domains (1) summary
      pfam05022
      Location:622 → 670
      SRP40_C; SRP40, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XVS4.1

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