U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ilys-2 Invertebrate-type lysozyme 2 [ Caenorhabditis elegans ]

    Gene ID: 183475, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ilys-2
    Official Full Name
    Invertebrate-type lysozyme 2
    Primary source
    WormBase:WBGene00016669
    Locus tag
    CELE_C45G7.2
    See related
    AllianceGenome:WB:WBGene00016669
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lysozyme activity. Involved in defense response to Gram-positive bacterium. Is expressed in intestine; nerve ring; and pm3. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ilys-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (2467678..2468879)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cadherin domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Invertebrate-type lysozyme 3 Neighboring gene lysozyme Neighboring gene Ground-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mechanism of biofilm-mediated stress resistance and lifespan extension in C. elegans. Smolentseva O, et al. Sci Rep, 2017 Aug 2. PMID 28769037, Free PMC Article
    2. GH18 family glycoside hydrolase Chitinase A of Salmonella enhances virulence by facilitating invasion and modulating host immune responses. Chandra K, et al. PLoS Pathog, 2022 Apr. PMID 35482710, Free PMC Article
    3. Impaired immune response and barrier function in GSPD-1-deficient C. elegans infected with Klebsiella pneumoniae. Yang WH, et al. Curr Res Microb Sci, 2023. PMID 36798906, Free PMC Article
    4. Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum. O'Rourke D, et al. Genome Res, 2006 Aug. PMID 16809667, Free PMC Article
    5. Diversification and adaptive sequence evolution of Caenorhabditis lysozymes (Nematoda: Rhabditidae). Schulenburg H, et al. BMC Evol Biol, 2008 Apr 19. PMID 18423043, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysozyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Invertebrate-type lysozyme 2
    NP_500207.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2467678..2468879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067806.3 → NP_500207.1  Invertebrate-type lysozyme 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500207.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76358
      Conserved Domains (1) summary
      pfam05497
      Location:17 → 135
      Destabilase; Destabilase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76358.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools