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    dyf-1 Tetratricopeptide repeat protein 30 homolog [ Caenorhabditis elegans ]

    Gene ID: 172122, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dyf-1
    Official Full Name
    Tetratricopeptide repeat protein 30 homolog
    Primary source
    WormBase:WBGene00001117
    Locus tag
    CELE_F54C1.5
    See related
    AllianceGenome:WB:WBGene00001117
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable intraciliary transport particle B binding activity. Involved in intraciliary transport; protein localization to plasma membrane; and protein polyglutamylation. Located in axonemal microtubule and ciliary basal body. Is expressed in amphid neurons; inner labial neurons; outer labial neurons; and phasmid neurons. Orthologous to human IFT70A (intraflagellar transport 70A) and IFT70B (intraflagellar transport 70B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dyf-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    13
    Sequence:
    Chromosome: I; NC_003279.8 (4989548..4994675, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene 1-alkyl-2-acetylglycerophosphocholine esterase Neighboring gene CILiary localization Neighboring gene Polycomb protein mes-3 Neighboring gene Decapping nuclease dom-3 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autoinhibition regulates the motility of the C. elegans intraflagellar transport motor OSM-3. Imanishi M, et al. J Cell Biol, 2006 Sep 25. PMID 17000874, Free PMC Article
    2. Amphid defective mutant of Caenorhabditis elegans. De Riso L, et al. Genetica, 1994. PMID 7896139
    3. Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling. Segref A, et al. Nat Commun, 2022 Oct 5. PMID 36198694, Free PMC Article
    4. Lipid modification of signal-transducing polypeptides in the free-living nematode Caenorhabditis elegans. Aspbury RA, et al. Biochem Soc Trans, 1995 Feb. PMID 7758740
    5. Intraflagellar transport: keeping the motors coordinated. Cole DG. Curr Biol, 2005 Oct 11. PMID 16213810

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables intraciliary transport particle B binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyglutamylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axonemal microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Tetratricopeptide repeat protein 30 homolog
    NP_491494.2
    • Confirmed by transcript evidence
    NP_871863.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4989548..4994675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059093.7 → NP_491494.2  Tetratricopeptide repeat protein 30 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491494.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I7G3, Q8I7G4
      Conserved Domains (3) summary
      sd00006
      Location:141 → 169
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:140 → 203
      TPR_11; TPR repeat
      pfam14559
      Location:19 → 85
      TPR_19; Tetratricopeptide repeat

    2. NM_182063.7 → NP_871863.1  Tetratricopeptide repeat protein 30 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871863.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I7G4
      Conserved Domains (3) summary
      sd00006
      Location:82 → 110
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:81 → 144
      TPR_11; TPR repeat
      pfam14559
      Location:402 → 462
      TPR_19; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I7G4.1

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