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    F22B8.7 MOSC domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180078, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F22B8.7
    Official Full Name
    MOSC domain-containing protein
    Primary source
    WormBase:WBGene00009049
    Locus tag
    CELE_F22B8.7
    See related
    AllianceGenome:WB:WBGene00009049
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable catalytic activity; molybdenum ion binding activity; and pyridoxal phosphate binding activity. Involved in regulation of protein deneddylation. Located in cytoplasm and nucleus. Orthologous to human MTARC1 (mitochondrial amidoxime reducing component 1) and MTARC2 (mitochondrial amidoxime reducing component 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F22B8.7 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (16094584..16097320)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Seven TM Receptor Neighboring gene G protein-coupled receptor;Seven TM Receptor Neighboring gene cystathionine gamma-lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1. Dorfman M, et al. Genetics, 2009 Aug. PMID 19528325, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of protein deneddylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MOSC domain-containing protein
    NP_507051.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16094584..16097320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074650.7 → NP_507051.2  MOSC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507051.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45394
      Conserved Domains (2) summary
      COG3217
      Location:45 → 339
      YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
      pfam03476
      Location:42 → 166
      MOSC_N; MOSC N-terminal beta barrel domain
    Nucleotide Protein
    Heading Accession and Version

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