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    sec-5 Exocyst complex component 2 [ Caenorhabditis elegans ]

    Gene ID: 174459, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sec-5
    Official Full Name
    Exocyst complex component 2
    Primary source
    WormBase:WBGene00004752
    Locus tag
    CELE_T23G7.4
    See related
    AllianceGenome:WB:WBGene00004752
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Predicted to be part of exocyst. Is expressed in several structures, including anal depressor muscle; excretory canal; hermaphrodite somatic gonadal cell; intestine; and tail neurons. Orthologous to human EXOC2 (exocyst complex component 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sec-5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    12
    Sequence:
    Chromosome: II; NC_003280.10 (9173166..9177152, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene G-patch domain-containing protein Neighboring gene Calcineurin-like phosphoesterase domain-containing protein Neighboring gene Transcription factor dpl-1 Neighboring gene RNA/RNP complex-1-interacting phosphatase homolog Neighboring gene RNA-binding protein sym-2;RRM domain-containing protein Neighboring gene Potassium channel domain-containing protein Neighboring gene Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Repurposing an endogenous degradation system for rapid and targeted depletion of C. elegans proteins. Armenti ST, et al. Development, 2014 Dec. PMID 25377555, Free PMC Article
    2. RAL-1 controls multivesicular body biogenesis and exosome secretion. Hyenne V, et al. J Cell Biol, 2015 Oct 12. PMID 26459596, Free PMC Article
    3. RAL-1 signaling regulates lipid composition in C. elegans. Wu Y, et al. MicroPubl Biol, 2024. PMID 38454952, Free PMC Article
    4. RAB-10 Regulates Dendritic Branching by Balancing Dendritic Transport. Taylor CA, et al. PLoS Genet, 2015 Dec. PMID 26633194, Free PMC Article
    5. Polarized exocyst-mediated vesicle fusion directs intracellular lumenogenesis within the C. elegans excretory cell. Armenti ST, et al. Dev Biol, 2014 Oct 1. PMID 25102190, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exocyst ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Exocyst complex component 2
    NP_495958.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9173166..9177152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063557.7 → NP_495958.1  Exocyst complex component 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495958.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22706
      Conserved Domains (2) summary
      pfam01833
      Location:13 → 95
      TIG; IPT/TIG domain
      pfam15469
      Location:201 → 377
      Sec5; Exocyst complex component Sec5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22706.1

    Gene LinkOut

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