U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    spp-1 Saposin B-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176452, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    spp-1
    Official Full Name
    Saposin B-type domain-containing protein
    Primary source
    WormBase:WBGene00004986
    Locus tag
    CELE_T07C4.4
    See related
    AllianceGenome:WB:WBGene00004986
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables pore-forming activity. Involved in defense response to other organism and pore formation in membrane of another organism. Part of pore complex. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See spp-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003281.10 (10355098..10355668, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene T-box transcription factor tbx-9 Neighboring gene T-box transcription factor tbx-8 Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene Orotidine 5'-phosphate decarboxylase Neighboring gene Rab GTPase-activating protein tbc-8

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The saposin-like protein SPP-12 is an antimicrobial polypeptide in the pharyngeal neurons of Caenorhabditis elegans and participates in defence against a natural bacterial pathogen. Hoeckendorf A, et al. Biochem J, 2012 Jul 15. PMID 22519640
    2. Resistance to antimicrobial peptides contributes to persistence of Salmonella typhimurium in the C. elegans intestine. Alegado RA, et al. Cell Microbiol, 2008 Jun. PMID 18221392
    3. Tasco®: a product of Ascophyllum nodosum enhances immune response of Caenorhabditis elegans against Pseudomonas aeruginosa infection. Kandasamy S, et al. Mar Drugs, 2012 Jan. PMID 22363222, Free PMC Article
    4. Antinematode activity of Violacein and the role of the insulin/IGF-1 pathway in controlling violacein sensitivity in Caenorhabditis elegans. Ballestriero F, et al. PLoS One, 2014. PMID 25295516, Free PMC Article
    5. Uridine monophosphate synthetase enables eukaryotic de novo NAD(+) biosynthesis from quinolinic acid. McReynolds MR, et al. J Biol Chem, 2017 Jul 7. PMID 28559281, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables pore-forming activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in innate immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pore formation in membrane of another organism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of pore complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Saposin B-type domain-containing protein
    NP_499290.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10355098..10355668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066889.8 → NP_499290.2  Saposin B-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499290.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22291
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools