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    ints-2 INTegrator complex Subunit homolog [ Caenorhabditis elegans ]

    Gene ID: 179921, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ints-2
    Official Full Name
    INTegrator complex Subunit homolog
    Primary source
    WormBase:WBGene00013877
    Locus tag
    CELE_ZC376.6
    See related
    AllianceGenome:WB:WBGene00013877
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. Orthologous to human INTS2 (integrator complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ints-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    17
    Sequence:
    Chromosome: V; NC_003283.11 (14185686..14192161)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Carboxylesterase type B domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene tRNA (guanine(26)-N(2))-dimethyltransferase Neighboring gene Stress activated transcription factor atfs-1 Neighboring gene BTB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes. Gómez-Orte E, et al. PLoS Genet, 2019 Feb. PMID 30807579, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    INTegrator complex Subunit homolog
    NP_001256569.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class ints
    NP_001256570.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class ints

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14185686..14192161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269641.2 → NP_001256570.1  INTegrator complex Subunit homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23271
      Conserved Domains (1) summary
      pfam14750
      Location:156 → 1118
      INTS2; Integrator complex subunit 2

    2. NM_001269640.4 → NP_001256569.1  INTegrator complex Subunit homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E5QCH1
      Conserved Domains (1) summary
      pfam14750
      Location:156 → 1122
      INTS2; Integrator complex subunit 2
    Nucleotide Protein
    Heading Accession and Version

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