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    hrg-3 Heme Responsive Gene [ Caenorhabditis elegans ]

    Gene ID: 179369, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hrg-3
    Official Full Name
    Heme Responsive Gene
    Primary source
    WormBase:WBGene00010256
    Locus tag
    CELE_F58E6.7
    See related
    AllianceGenome:WB:WBGene00010256
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables heme binding activity and heme transmembrane transporter activity. Involved in defense response to Gram-negative bacterium and heme transport. Located in extracellular space. Is expressed in intestinal cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hrg-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (9756468..9757019)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene Uncharacterized protein Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene Homeobox protein unc-42 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histidine residues are important for preserving the structure and heme binding to the C. elegans HRG-3 heme-trafficking protein. Marciano O, et al. J Biol Inorg Chem, 2015 Dec. PMID 26531103
    2. An intercellular heme-trafficking protein delivers maternal heme to the embryo during development in C. elegans. Chen C, et al. Cell, 2011 May 27. PMID 21620137, Free PMC Article
    3. Heme metabolism and erythropoiesis. Chung J, et al. Curr Opin Hematol, 2012 May. PMID 22406824, Free PMC Article
    4. Heme utilization in the Caenorhabditis elegans hypodermal cells is facilitated by heme-responsive gene-2. Chen C, et al. J Biol Chem, 2012 Mar 16. PMID 22303006, Free PMC Article
    5. HRG-9 homologues regulate haem trafficking from haem-enriched compartments. Sun F, et al. Nature, 2022 Oct. PMID 36261532, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heme transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Heme Responsive Gene
    NP_505518.2
    • Product from WormBase gene class hrg;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9756468..9757019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073117.6 → NP_505518.2  Heme Responsive Gene [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505518.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20983
    Nucleotide Protein
    Heading Accession and Version

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