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    tpxl-1 TPX2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171786, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tpxl-1
    Official Full Name
    TPX2 domain-containing protein
    Primary source
    WormBase:WBGene00021470
    Locus tag
    CELE_Y39G10AR.12
    See related
    AllianceGenome:WB:WBGene00021470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein kinase binding activity. Involved in astral microtubule organization and mitotic spindle assembly. Located in astral microtubule; meiotic spindle; and spindle pole centrosome. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See tpxl-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (2297392..2304397, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Cyclin-dependent kinase 7 Neighboring gene TPR_MLP1_2 domain-containing protein Neighboring gene Ectopic P granules protein 2 Neighboring gene Inner centromere protein ARK-binding domain-containing protein Neighboring gene WD_REPEATS_REGION domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TPX or not TPX? Karsenti E. Mol Cell, 2005 Aug 19. PMID 16109366
    2. Analyzing the effects of delaying aster separation on furrow formation during cytokinesis in the Caenorhabditis elegans embryo. Lewellyn L, et al. Mol Biol Cell, 2010 Jan 1. PMID 19889842, Free PMC Article
    3. An allometric relationship between mitotic spindle width, spindle length, and ploidy in Caenorhabditis elegans embryos. Hara Y, et al. Mol Biol Cell, 2013 May. PMID 23468523, Free PMC Article
    4. Aurora A and cortical flows promote polarization and cytokinesis by inducing asymmetric ECT-2 accumulation. Longhini KM, et al. Elife, 2022 Dec 19. PMID 36533896, Free PMC Article
    5. The KLP-7 Residue S546 Is a Putative Aurora Kinase Site Required for Microtubule Regulation at the Centrosome in C. elegans. Han X, et al. PLoS One, 2015. PMID 26168236, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. polar clearing is an active process that requires activation of Aurora A kinase by TPXL-1. TPXL-1 concentrates on astral microtubules coincident with polar clearing in anaphase, and its ability to recruit Aurora A and activate its kinase activity are essential for clearing.
      Title: TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis.
    2. Centrosome size sets mitotic spindle length by controlling the length scale of a TPXL-1 gradient along spindle microtubules.
      Title: Centrosome size sets mitotic spindle length in Caenorhabditis elegans embryos.
    3. Activation and targeting of Aurora A appears to be an ancient and conserved function of TPX2 that plays a central role in mitotic spindle assembly.
      Title: An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in astral microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in astral microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TPX2 domain-containing protein
    NP_740805.1
    • Confirmed by transcript evidence
    NP_740806.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2297392..2304397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170821.7 → NP_740805.1  TPX2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDE7
      Conserved Domains (1) summary
      PHA03247
      Location:132 → 455
      PHA03247; large tegument protein UL36; Provisional

    2. NM_170822.8 → NP_740806.1  TPX2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740806.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WSN6
      Conserved Domains (1) summary
      PHA03247
      Location:102 → 455
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein
    Heading Accession and Version

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