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    riok-2 Serine/threonine-protein kinase RIO2 [ Caenorhabditis elegans ]

    Gene ID: 173322, updated on 9-Dec-2024

    Summary

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    Official Symbol
    riok-2
    Official Full Name
    Serine/threonine-protein kinase RIO2
    Primary source
    WormBase:WBGene00013688
    Locus tag
    CELE_Y105E8B.3
    See related
    AllianceGenome:WB:WBGene00013688
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein kinase activity. Involved in nematode larval development. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol and nucleus. Orthologous to human RIOK2 (RIO kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See riok-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (14652116..14657275)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein AF-9 homolog Neighboring gene BTB and MATH domain-containing protein 40 Neighboring gene Hypoxanthine phosphoribosyltransferase Neighboring gene ncRNA Neighboring gene BZIP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Flatworms have lost the right open reading frame kinase 3 gene during evolution. Breugelmans B, et al. Sci Rep, 2015 May 15. PMID 25976756, Free PMC Article
    2. Bioinformatic exploration of RIO protein kinases of parasitic and free-living nematodes. Breugelmans B, et al. Int J Parasitol, 2014 Oct 1. PMID 25038443
    3. Atypical (RIO) protein kinases from Haemonchus contortus--promise as new targets for nematocidal drugs. Campbell BE, et al. Biotechnol Adv, 2011 May-Jun. PMID 21262337
    4. Investigating the role of RIO protein kinases in Caenorhabditis elegans. Mendes TK, et al. PLoS One, 2015. PMID 25688864, Free PMC Article
    5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, small subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein kinase RIO2
    NP_493544.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14652116..14657275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061143.9 → NP_493544.2  Serine/threonine-protein kinase RIO2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493544.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95Q34
      Conserved Domains (3) summary
      COG0478
      Location:6 → 314
      RIO2; RIO-like serine/threonine protein kinase fused to N-terminal HTH domain [Signal transduction mechanisms]
      cd05144
      Location:94 → 276
      RIO2_C; C-terminal catalytic domain of the atypical protein serine kinase, RIO2 kinase
      pfam09202
      Location:9 → 91
      Rio2_N; Rio2, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95Q34.2

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