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    tftc-1 Transcription Factor ThreeC subunit (GTF3C homolog) [ Caenorhabditis elegans ]

    Gene ID: 177024, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tftc-1
    Official Full Name
    Transcription Factor ThreeC subunit (GTF3C homolog)
    Primary source
    WormBase:WBGene00021423
    Locus tag
    CELE_Y38F2AR.5
    See related
    AllianceGenome:WB:WBGene00021423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and transcription initiation at RNA polymerase III promoter. Predicted to be part of transcription factor TFIIIC complex. Orthologous to human GTF3C1 (general transcription factor IIIC subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tftc-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    21
    Sequence:
    Chromosome: IV; NC_003282.8 (2349271..2383041)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene AAA+ ATPase domain-containing protein Neighboring gene Complex I assembly factor TIMMDC1, mitochondrial;Transmembrane protein;Uncharacterized protein Neighboring gene ncRNA Neighboring gene Protein transport protein Sec61 subunit beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    2. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 5S class rRNA transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase III promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase III promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of transcription factor TFIIIC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIIC complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transcription Factor ThreeC subunit (GTF3C homolog)
    NP_001294528.1
    • Product from WormBase gene class tftc;
      Confirmed by transcript evidence
    NP_001294529.1
    • Product from WormBase gene class tftc;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2349271..2383041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307599.4 → NP_001294528.1  Transcription Factor ThreeC subunit (GTF3C homolog) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294528.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBT1
      Conserved Domains (1) summary
      cd16169
      Location:221 → 310
      Tau138_eWH; extended winged-helix domain of tau138 and related proteins

    2. NM_001307600.3 → NP_001294529.1  Transcription Factor ThreeC subunit (GTF3C homolog) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294529.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PC56
      Conserved Domains (1) summary
      cd16169
      Location:221 → 310
      Tau138_eWH; extended winged-helix domain of tau138 and related proteins
    Nucleotide Protein
    Heading Accession and Version

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