unc-115 Actin-binding lim zn-finger protein limatin involved in axon guidance [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-115
Official Full Name: Actin-binding lim zn-finger protein limatin involved in axon guidance
Primary source: WormBase:WBGene00006839
Locus tag: CELE_F09B9.2
See related: AllianceGenome:WB:WBGene00006839
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables actin filament binding activity. Involved in neuron projection morphogenesis; regulation of filopodium assembly; and regulation of lamellipodium assembly. Located in basal plasma membrane and cytoplasm. Is expressed in several structures, including PDE; excretory cell; pharynx; somatic nervous system; and vulva. Orthologous to several human genes including ABLIM2 (actin binding LIM protein family member 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-115 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 12

Sequence:: Chromosome: X; NC_003284.9 (10146892..10153142)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UNC-115/abLIM and UNC-34/Enabled control growth cone filopodia formation, possibly in parallel to Arp2/3.
Title: The Arp2/3 complex, UNC-115/abLIM, and UNC-34/Enabled regulate axon guidance and growth cone filopodia formation in Caenorhabditis elegans.
UNC-115 is an actin-binding protein that acts downstream of Rac signaling in axon pathfinding
Title: The actin-binding protein UNC-115 is an effector of Rac signaling during axon pathfinding in C. elegans.
Data show that UNC-115 is a novel regulator of the formation of lamellipodia and filopodia in neurons, possibly in the growth cone during axon pathfinding.
Title: The actin-binding protein UNC-115/abLIM controls formation of lamellipodia and filopodia and neuronal morphogenesis in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F09B9.2 (e-PCR)
- UniSTS:315231

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Actin-binding lim zn-finger protein limatin involved in axon guidance

NP_001024542.1

Confirmed by transcript evidence

NP_509702.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

10146892..10153142

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077301.9 → NP_509702.3 Actin-binding lim zn-finger protein limatin involved in axon guidance [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509702.3

Status: REVIEWED

UniProtKB/TrEMBL

O77133, Q19240

Conserved Domains (5) summary

smart00153
Location:590 → 625

VHP; Villin headpiece domain

cd09327
Location:5 → 57

LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins

cd09329
Location:117 → 168

LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins

cd09330
Location:176 → 231

LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins

pfam01056
Location:336 → 466

Myc_N; Myc amino-terminal region
NM_001029371.8 → NP_001024542.1 Actin-binding lim zn-finger protein limatin involved in axon guidance [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024542.1

Status: REVIEWED

UniProtKB/TrEMBL

O77133, Q95QM5

Conserved Domains (5) summary

smart00153
Location:604 → 639

VHP; Villin headpiece domain

cd09327
Location:19 → 71

LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins

cd09329
Location:131 → 182

LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins

cd09330
Location:190 → 245

LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins

pfam01056
Location:350 → 480

Myc_N; Myc amino-terminal region