ima-3 Importin subunit alpha-3 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: ima-3
Official Full Name: Importin subunit alpha-3
Primary source: WormBase:WBGene00002074
Locus tag: CELE_F32E10.4
See related: AllianceGenome:WB:WBGene00002074
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription factor binding activity; nuclear import signal receptor activity; and nuclear localization sequence binding activity. Involved in several processes, including NLS-bearing protein import into nucleus; nuclear pore organization; and positive regulation of axon extension involved in regeneration. Located in cytoplasm and nuclear envelope. Part of nuclear pore. Is expressed in several structures, including germ line; gonad; intestine; muscle cell; and pharynx. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 88. Orthologous to human KPNA3 (karyopherin subunit alpha 3) and KPNA4 (karyopherin subunit alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear import signal receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in NLS-bearing protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear pore organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension involved in regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_501227.1

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The following sections contain reference sequences that belong to a specific genome build. Explain