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    dnj-10 DnaJ homolog dnj-10 [ Caenorhabditis elegans ]

    Gene ID: 176211, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dnj-10
    Official Full Name
    DnaJ homolog dnj-10
    Primary source
    WormBase:WBGene00001028
    Locus tag
    CELE_F22B7.5
    See related
    AllianceGenome:WB:WBGene00001028
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable unfolded protein binding activity. Involved in embryo development and nematode larval development. Predicted to be active in mitochondrion. Is expressed in head; intestine; pharynx; and tail. Orthologous to human DNAJA3 (DnaJ heat shock protein family (Hsp40) member A3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dnj-10 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (8631165..8633565)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Homeobox protein engrailed-like ceh-16 Neighboring gene DNA polymerase kappa Neighboring gene G-protein regulator 1 Neighboring gene TWiK family of potassium channels protein 7 Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene Fungus-induced protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel putative interactors of FZO-1/mitofusin 2 identified using large-scale yeast two-hybrid screening in C. elegans. Dhananjay S, et al. MicroPubl Biol, 2022. PMID 36530473, Free PMC Article
    2. Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Nargund AM, et al. Science, 2012 Aug 3. PMID 22700657, Free PMC Article
    3. Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans. Sladowska M, et al. PLoS Biol, 2021 Jul. PMID 34252079, Free PMC Article
    4. Involvement of the actin cytoskeleton and homotypic membrane fusion in ER dynamics in Caenorhabditis elegans. Poteryaev D, et al. Mol Biol Cell, 2005 May. PMID 15716356, Free PMC Article
    5. Allele-specific mitochondrial stress induced by Multiple Mitochondrial Dysfunctions Syndrome 1 pathogenic mutations modeled in Caenorhabditis elegans. Kropp PA, et al. PLoS Genet, 2021 Aug. PMID 34449775, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DnaJ homolog dnj-10
    NP_498901.1
    • Confirmed by transcript evidence
    NP_498902.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8631165..8633565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066501.4 → NP_498902.1  DnaJ homolog dnj-10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498902.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34408, Q8TA83, Q95QJ6
      Conserved Domains (4) summary
      cd10719
      Location:191 → 252
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:165 → 372
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:41 → 387
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:44 → 105
      DnaJ; DnaJ domain

    2. NM_066500.7 → NP_498901.1  DnaJ homolog dnj-10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498901.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8TA83
      Conserved Domains (4) summary
      cd10719
      Location:191 → 252
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:165 → 372
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:41 → 387
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:44 → 105
      DnaJ; DnaJ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TA83.1

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