pat-10 EF-hand domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pat-10
Official Full Name: EF-hand domain-containing protein
Primary source: WormBase:WBGene00003934
Locus tag: CELE_F54C1.7
See related: AllianceGenome:WB:WBGene00003934
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables troponin I binding activity. Involved in embryo development; muscle contraction; and skeletal muscle thin filament assembly. Located in contractile muscle fiber. Is expressed in body wall musculature; gonadal sheath cell; rectal muscle; and vulval muscle. Orthologous to human CALML6 (calmodulin like 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pat-10 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (5018783..5020086, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of pat-10 caused a collapse of the actin cytoskeleton, stress resistance, and life span. Overexpression of pat-10 increased actin filament stability, thermotolerance, and longevity, indicating that in addition to chaperone regulation, HSF-1 has a prominent role in cytoskeletal integrity, ensuring cellular function during stress and aging.
Title: HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span.
Troponin C and tropomyosin are the actin-linked regulators for contraction of ovarian muscle in the C. elegans reproductive system.
Title: Tropomyosin and troponin are required for ovarian contraction in the Caenorhabditis elegans reproductive system.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54C1.7 (e-PCR)
- UniSTS:315915

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables structural constituent of muscle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables troponin I binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle thin filament assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in contractile muscle fiber	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: EF-hand domain-containing protein

NP_491501.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5018783..5020086 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059100.8 → NP_491501.1 EF-hand domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491501.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EF37

Conserved Domains (2) summary

cd15897
Location:21 → 47

EFh_PEF; EF-hand motif [structural motif]

cl25352
Location:16 → 156

EFh_PEF; The penta-EF hand (PEF) family