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    nipi-4 Protein nipi-4 [ Caenorhabditis elegans ]

    Gene ID: 179167, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nipi-4
    Official Full Name
    Protein nipi-4
    Primary source
    WormBase:WBGene00077712
    Locus tag
    CELE_F40A3.5
    See related
    AllianceGenome:WB:WBGene00077712
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity and protein kinase activity. Involved in defense response to fungus; positive regulation of gene expression; and response to wounding. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in hypodermis. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nipi-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (7868461..7870807, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene SLBB domain-containing protein Neighboring gene DUF2975 domain-containing protein Neighboring gene Envelope glycoprotein N Neighboring gene Phosphatidylethanolamine-binding protein;Phosphatidylethanolamine-binding protein homolog F40A3.3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression. Labed SA, et al. PLoS One, 2012. PMID 22470487, Free PMC Article
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein nipi-4
    NP_505028.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      7868461..7870807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072627.7 → NP_505028.3  Protein nipi-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505028.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16262
      Conserved Domains (2) summary
      pfam07714
      Location:87 → 350
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:86 → 350
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16262.3

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