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    spv-1 F-BAR domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174278, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spv-1
    Official Full Name
    F-BAR domain-containing protein
    Primary source
    WormBase:WBGene00014051
    Locus tag
    CELE_ZK669.1
    See related
    AllianceGenome:WB:WBGene00014051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTPase activator activity. Involved in several processes, including cell-cell junction assembly; negative regulation of smooth muscle contraction; and regulation of protein localization. Located in apical plasma membrane and cell-cell junction. Is expressed in head neurons; hypodermis; spermatheca; spermathecal cell; and tail neurons. Orthologous to several human genes including GMIP (GEM interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spv-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    21
    Sequence:
    Chromosome: II; NC_003280.10 (7912090..7928700, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DNA repair protein REV1 Neighboring gene Bestrophin homolog Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Gamma-interferon-inducible lysosomal thiol reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanotransduction: feeling the squeeze in the C. elegans reproductive system. Cram EJ. Curr Biol, 2015 Jan 19. PMID 25602308, Free PMC Article
    2. Caffeine induces high expression of cyp-35A family genes and inhibits the early larval development in Caenorhabditis elegans. Min H, et al. Mol Cells, 2015 Mar. PMID 25591395, Free PMC Article
    3. The RhoGAP SPV-1 regulates calcium signaling to control the contractility of the Caenorhabditis elegans spermatheca during embryo transits. Bouffard J, et al. Mol Biol Cell, 2019 Mar 21. PMID 30726159, Free PMC Article
    4. Transient membrane localization of SPV-1 drives cyclical actomyosin contractions in the C. elegans spermatheca. Tan PY, et al. Curr Biol, 2015 Jan 19. PMID 25532891
    5. PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector. Myagmar BE, et al. Biochem Biophys Res Commun, 2005 Apr 15. PMID 15752761

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization to cell leading edge IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization to cell-cell junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-BAR domain-containing protein
    NP_001359761.1
    • Confirmed by transcript evidence
    NP_001367277.1
    • Confirmed by transcript evidence
    NP_001368151.1
    • Partially confirmed by transcript evidence
    NP_495666.4
    • Confirmed by transcript evidence
    NP_495667.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7912090..7928700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063265.8 → NP_495666.4  F-BAR domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495666.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF80
      Conserved Domains (3) summary
      smart00109
      Location:537 → 583
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00055
      Location:195 → 278
      FCH; Fes/CIP4 homology domain
      smart00324
      Location:610 → 796
      RhoGAP; GTPase-activator protein for Rho-like GTPases

    2. NM_063266.6 → NP_495667.2  F-BAR domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495667.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFY2
      Conserved Domains (2) summary
      smart00109
      Location:117 → 163
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00324
      Location:190 → 376
      RhoGAP; GTPase-activator protein for Rho-like GTPases

    3. NM_001373749.2 → NP_001359761.1  F-BAR domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECK6
      Conserved Domains (2) summary
      smart00109
      Location:79 → 125
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00324
      Location:152 → 338
      RhoGAP; GTPase-activator protein for Rho-like GTPases

    4. NM_001381512.1 → NP_001367277.1  F-BAR domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG95
      Conserved Domains (4) summary
      PTZ00121
      Location:195 → 343
      PTZ00121; MAEBL; Provisional
      smart00055
      Location:131 → 214
      FCH; Fes/CIP4 homology domain
      smart00324
      Location:546 → 732
      RhoGAP; GTPase-activator protein for Rho-like GTPases
      cl00040
      Location:473 → 521
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    5. NM_001381513.1 → NP_001368151.1  F-BAR domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      J7S142
      Conserved Domains (4) summary
      PTZ00121
      Location:144 → 292
      PTZ00121; MAEBL; Provisional
      smart00055
      Location:80 → 163
      FCH; Fes/CIP4 homology domain
      smart00324
      Location:495 → 681
      RhoGAP; GTPase-activator protein for Rho-like GTPases
      cl00040
      Location:422 → 470
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    Nucleotide Protein
    Heading Accession and Version

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