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    atg-16.2 Autophagic-related protein 16.2 [ Caenorhabditis elegans ]

    Gene ID: 174067, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atg-16.2
    Official Full Name
    Autophagic-related protein 16.2
    Primary source
    WormBase:WBGene00019427
    Locus tag
    CELE_K06A1.5
    See related
    AllianceGenome:WB:WBGene00019427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-membrane adaptor activity. Involved in several processes, including defense response to Gram-positive bacterium; germ cell proliferation; and macroautophagy. Located in cytoplasm. Is expressed in body wall musculature; embryonic cell; intestine; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in inflammatory bowel disease 10. Orthologous to human ATG16L1 (autophagy related 16 like 1) and ATG16L2 (autophagy related 16 like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See atg-16.2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (6450889..6453391, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class Z;Transmembrane protein Neighboring gene Nuclear hormone receptor family member nhr-22 Neighboring gene Transcription factor aptf-1 Neighboring gene Diacylglycerol kinase;Putative diacylglycerol kinase K06A1.6 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronal waste management: new roles for autophagy genes in the extrusion of protein aggregates and in longevity. Sun LH, et al. Autophagy, 2024 Jul. PMID 38411179,
    2. A Non-Cell-Autonomous Role of BEC-1/BECN1/Beclin1 in Coordinating Cell-Cycle Progression and Stem Cell Proliferation during Germline Development. Ames K, et al. Curr Biol, 2017 Mar 20. PMID 28285998, Free PMC Article
    3. The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System. Xiong Q, et al. Cells, 2018 Dec 20. PMID 30577509, Free PMC Article
    4. Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway. Keith SA, et al. PLoS Genet, 2016 Feb. PMID 26828939, Free PMC Article
    5. The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway. Zhang H, et al. Autophagy, 2013 Dec. PMID 24185444, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in aggrephagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in aggrephagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in germ cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Atg12-Atg5-Atg16 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Autophagic-related protein 16.2
    NP_495299.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6450889..6453391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062898.4 → NP_495299.2  Autophagic-related protein 16.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495299.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09406
      Conserved Domains (5) summary
      COG2319
      Location:231 → 499
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:241 → 524
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08614
      Location:11 → 181
      ATG16; Autophagy protein 16 (ATG16)
      sd00039
      Location:294 → 330
      7WD40; WD40 repeat [structural motif]
      cl11531
      Location:107 → 175
      DUF904; Protein of unknown function (DUF904)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09406.2

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