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    sft-4 Surfeit locus protein 4 homolog [ Caenorhabditis elegans ]

    Gene ID: 180843, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sft-4
    Official Full Name
    Surfeit locus protein 4 homolog
    Primary source
    WormBase:WBGene00004788
    Locus tag
    CELE_C54H2.5
    See related
    AllianceGenome:WB:WBGene00004788
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cargo receptor activity. Involved in several processes, including negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of vulval development; and protein exit from endoplasmic reticulum. Located in endoplasmic reticulum exit site and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary muscle; excretory cell; hypodermis; reproductive system; and vulval precursor cell. Orthologous to human SURF4 (surfeit 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sft-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (5778875..5780722, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene C2 NT-type domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene ZP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Large-scale identification of Caenorhabditis elegans proteins by multidimensional liquid chromatography-tandem mass spectrometry. Mawuenyega KG, et al. J Proteome Res, 2003 Jan-Feb. PMID 12643540
    2. SFT-4/Surf4 control ER export of soluble cargo proteins and participate in ER exit site organization. Saegusa K, et al. J Cell Biol, 2018 Jun 4. PMID 29643117, Free PMC Article
    3. Surfeit locus gene homologs are widely distributed in invertebrate genomes. Armes N, et al. Mol Cell Biol, 1996 Oct. PMID 8816471, Free PMC Article
    4. Functional characterization in Caenorhabditis elegans of transmembrane worm-human orthologs. Henricson A, et al. BMC Genomics, 2004 Nov 8. PMID 15533247, Free PMC Article
    5. An in vivo EGF receptor localization screen in C. elegans Identifies the Ezrin homolog ERM-1 as a temporal regulator of signaling. Haag A, et al. PLoS Genet, 2014 May. PMID 24785082, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cargo receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein exit from endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Surfeit locus protein 4 homolog
    NP_508970.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5778875..5780722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076569.12 → NP_508970.1  Surfeit locus protein 4 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508970.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18006, Q18864
      Conserved Domains (1) summary
      pfam02077
      Location:11 → 277
      SURF4; SURF4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18864.1

    Gene LinkOut

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