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    mig-1 Frizzled-4 [ Caenorhabditis elegans ]

    Gene ID: 171677, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mig-1
    Official Full Name
    Frizzled-4
    Primary source
    WormBase:WBGene00003238
    Locus tag
    CELE_Y34D9B.1
    See related
    AllianceGenome:WB:WBGene00003238
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Involved in several processes, including mitochondrial unfolded protein response; neuron migration; and positive regulation of axon guidance. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in anal depressor muscle; head muscle; intestine; and neurons. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (frizzled class receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mig-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (948569..957456, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Zinc metalloproteinase nas-30 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Trp Neighboring gene ZP domain-containing protein Neighboring gene SHC-transforming protein homolog 1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Temporal precision of regulated gene expression. Gupta S, et al. PLoS Comput Biol, 2018 Jun. PMID 29879102, Free PMC Article
    2. Upstream plasticity and downstream robustness in evolution of molecular networks. Maslov S, et al. BMC Evol Biol, 2004 Mar 8. PMID 15070432, Free PMC Article
    3. The use of double-stranded RNA to knock down specific gene activity. Montgomery MK. Methods Mol Biol, 2004. PMID 15020807
    4. TetraThymosinbeta is required for actin dynamics in Caenorhabditis elegans and acts via functionally different actin-binding repeats. Van Troys M, et al. Mol Biol Cell, 2004 Oct. PMID 15269284, Free PMC Article
    5. Gene structure and molecular analysis of Arabidopsis thaliana ALWAYS EARLY homologs. Bhatt AM, et al. Gene, 2004 Jul 21. PMID 15246533

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Wnt receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial unfolded protein response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in motor neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in motor neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of anterior/posterior axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of motor neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of motor neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sensory neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Frizzled-4
    NP_001021744.1
    • Partially confirmed by transcript evidence
    NP_490796.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      948569..957456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026573.4 → NP_001021744.1  Frizzled-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N532
      Conserved Domains (2) summary
      cl02447
      Location:23 → 148
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
      cl21561
      Location:257 → 328
      7tm_4; Olfactory receptor

    2. NM_058395.6 → NP_490796.2  Frizzled-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490796.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF44
      Conserved Domains (2) summary
      cl02447
      Location:23 → 148
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
      cl21561
      Location:253 → 324
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version

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