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    fib-1 rRNA 2'-O-methyltransferase fibrillarin [ Caenorhabditis elegans ]

    Gene ID: 179999, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fib-1
    Official Full Name
    rRNA 2'-O-methyltransferase fibrillarin
    Primary source
    WormBase:WBGene00001423
    Locus tag
    CELE_T01C3.7
    See related
    AllianceGenome:WB:WBGene00001423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity; histone H2AQ104 methyltransferase activity; and rRNA methyltransferase activity. Involved in nucleologenesis and positive regulation of translation. Located in nucleolus and nucleoplasm. Orthologous to several human genes including FBL (fibrillarin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fib-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (15000653..15001969, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Spore coat protein;Transmembrane protein Neighboring gene Small ribosomal subunit protein uS9 Neighboring gene MUTator Neighboring gene Protein hrde-2 Neighboring gene Ionotropic glutamate receptor C-terminal domain-containing protein;PBPe domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleolar fibrillarin is an evolutionarily conserved regulator of bacterial pathogen resistance. Tiku V, et al. Nat Commun, 2018 Sep 6. PMID 30190478, Free PMC Article
    2. The Caenorhabditis elegans orthologue of the human gene responsible for spinal muscular atrophy is a maternal product critical for germline maturation and embryonic viability. Miguel-Aliaga I, et al. Hum Mol Genet, 1999 Nov. PMID 10545592
    3. RBD-1, a nucleolar RNA-binding protein, is essential for Caenorhabditis elegans early development through 18S ribosomal RNA processing. Saijou E, et al. Nucleic Acids Res, 2004. PMID 14872060, Free PMC Article
    4. The nucleolus of Caenorhabditis elegans. Lee LW, et al. J Biomed Biotechnol, 2012. PMID 22577294, Free PMC Article
    5. New insights into polycistronic transcripts in eukaryotes. Pi H, et al. Chang Gung Med J, 2009 Sep-Oct. PMID 19840506

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AQ104 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in box C/D sno(s)RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleologenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Cajal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box C/D methylation guide snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rRNA 2'-O-methyltransferase fibrillarin
    NP_506691.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15000653..15001969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074290.7 → NP_506691.1  rRNA 2'-O-methyltransferase fibrillarin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506691.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22053
      Conserved Domains (1) summary
      PTZ00146
      Location:115 → 351
      PTZ00146; fibrillarin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22053.1

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