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    csp-3 Non-catalytic caspase homolog csp-3 [ Caenorhabditis elegans ]

    Gene ID: 190006, updated on 9-Dec-2024

    Summary

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    Official Symbol
    csp-3
    Official Full Name
    Non-catalytic caspase homolog csp-3
    Primary source
    WormBase:WBGene00000821
    Locus tag
    CELE_Y47H9C.6
    See related
    AllianceGenome:WB:WBGene00000821
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables caspase binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and zymogen binding activity. Involved in positive regulation of behavior; positive regulation of embryonic development; and regulation of apoptotic process. Located in cytoplasm. Is expressed in several structures, including germ line. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See csp-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (11888501..11890558, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DnaJ homolog subfamily C member 10;Thioredoxin domain-containing protein Neighboring gene pre-microRNA mir-5545 Neighboring gene Translation initiation factor eIF2B subunit beta Neighboring gene NACHT_N domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caspase protocols in Caenorhabditis elegans. Lee ES, et al. Methods Mol Biol, 2014. PMID 24567097
    2. Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3. Geng X, et al. Nat Struct Mol Biol, 2008 Oct. PMID 18776901, Free PMC Article
    3. Identification of multiple Caenorhabditis elegans caspases and their potential roles in proteolytic cascades. Shaham S. J Biol Chem, 1998 Dec 25. PMID 9857046
    4. Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells. Geng X, et al. Cell Death Differ, 2009 Oct. PMID 19575016, Free PMC Article
    5. Caspases: an ancient cellular sword of Damocles. Boyce M, et al. Cell Death Differ, 2004 Jan. PMID 14647235

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables caspase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zymogen binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process involved in development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process involved in development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of egg-laying behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Non-catalytic caspase homolog csp-3
    NP_493011.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      11888501..11890558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060610.4 → NP_493011.2  Non-catalytic caspase homolog csp-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493011.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECW5
      Conserved Domains (1) summary
      cl00042
      Location:11 → 132
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    RNA

    1. NR_138525.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ECW5.1

    Gene LinkOut

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