rnt-1 Runt-related transcription factor rnt-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rnt-1
Official Full Name: Runt-related transcription factor rnt-1
Primary source: WormBase:WBGene00004393
Locus tag: CELE_B0414.2
See related: AllianceGenome:WB:WBGene00004393
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of locomotion involved in locomotory behavior; and regulation of gene expression. Acts upstream of or within dopamine metabolic process. Located in nucleus. Part of core-binding activity factor complex. Is expressed in several structures, including body wall musculature; dopaminergic neurons; intestine; ray precursor cell; and seam cell. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; breast cancer (multiple); carcinoma (multiple); osteochondrodysplasia (multiple); and pancreatic cancer. Orthologous to several human genes including RUNX2 (RUNX family transcription factor 2) and RUNX3 (RUNX family transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rnt-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (5783811..5788610)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNT-1/BRO-1 appears to render POP-1 below the level required for its repressor function, which converts differentiation into self-renewal; conserved Runx/CBFbeta-type stem cell regulators switch asymmetric to proliferative cell division by opposing TCF-related transcriptional repression
Title: C. elegans Runx/CBFβ suppresses POP-1 TCF to convert asymmetric to proliferative division of stem cell-like seam cells.
these findings identify a novel role for rnt-1 in limiting DA neurotransmission and suggest that loss of RNT-1 may disrupt function of both DA neurons and body wall muscle to drive Swip.
Title: Dopamine-dependent, swimming-induced paralysis arises as a consequence of loss of function mutations in the RUNX transcription factor RNT-1.
rnt-1 is regulated at the protein level for its role in the immediate response to environmental challenges in the intestine.
Title: Stabilization of RNT-1 protein, runt-related transcription factor (RUNX) protein homolog of Caenorhabditis elegans, by oxidative stress through mitogen-activated protein kinase pathway.
indicate that BRO-1 and RNT-1 form a cell proliferation-promoting complex, and that BRO-1 increases both the affinity and specificity of RNT-1-DNA interactions
Title: The C. elegans CBFbeta homologue BRO-1 interacts with the Runx factor, RNT-1, to promote stem cell proliferation and self-renewal.
Data suggest that RNT-1 functionally cooperates with the SMA-4 proteins to regulate body size and male tail development in C. elegans.
Title: RNT-1, the C. elegans homologue of mammalian RUNX transcription factors, regulates body size and male tail development.
RNT-1/MAB-2 functions with POP-1 to control the asymmetry of the T cell division.
Title: The C. elegans RUNX transcription factor RNT-1/MAB-2 is required for asymmetrical cell division of the T blast cell.
rnt-1, encoded by male abnormal 2 (mab-2), is a rate-limiting regulator of stem cell-like lateral hypodermal (seam) cell proliferation in C. elegans
Title: mab-2 encodes RNT-1, a C. elegans Runx homologue essential for controlling cell proliferation in a stem cell-like developmental lineage.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0414.2 (e-PCR)
- UniSTS:321895

B0414.3 (e-PCR)
- UniSTS:315328

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric stem cell division	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of stem cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stem cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of core-binding factor complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Runt-related transcription factor rnt-1

NP_001370335.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5783811..5788610

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383147.2 → NP_001370335.1 Runt-related transcription factor rnt-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EFQ5

Conserved Domains (1) summary

pfam00853
Location:22 → 137

Runt; Runt domain