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    SA1 Stromalin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33974, updated on 17-Dec-2024

    Summary

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    Official Symbol
    SA1provided by FlyBase
    Official Full Name
    Stromalin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0020616
    Locus tag
    Dmel_CG3423
    See related
    AllianceGenome:FB:FBgn0020616
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3423; Dmel\CG3423; DmSA; DSA; DSA1; ESTS:92H2T; SA; SA-1; Scc3; SCC3; stromalin
    Summary
    Enables chromatin binding activity. Involved in neuron remodeling and synaptonemal complex assembly. Located in chromosome and spindle pole. Part of cohesin complex. Human ortholog(s) of this gene implicated in Holoprosencephaly 13, X-linked; Mullegama-Klein-Martinez syndrome; autosomal dominant intellectual developmental disorder 47; primary ovarian insufficiency 8; and spermatogenic failure 61. Orthologous to several human genes including STAG1 (STAG1 cohesin complex component) and STAG2 (STAG2 cohesin complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SA1 in Genome Data Viewer
    Location:
    27C7-27C7; 2-23 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6950421..6954586)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6950421..6954586)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene interference hedgehog Neighboring gene Gas41 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ada2a-containing complex component 1 Neighboring gene 3-Hydroxymethyl-3-methylglutaryl-CoA lyase Neighboring gene septin interacting protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression of stromalin protein from Drosophila melanogaster: homologous to mammalian stromalin family of nuclear proteins. Valdeolmillos A, et al. DNA Cell Biol, 1998 Aug. PMID 9726252
    2. Drosophila cohesins DSA1 and Drad21 persist and colocalize along the centromeric heterochromatin during mitosis. Valdeolmillos A, et al. Biol Cell, 2004 Aug. PMID 15325074
    3. CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions. Kaushal A, et al. Nat Commun, 2021 Feb 12. PMID 33579945, Free PMC Article
    4. When size does not matter: pairing sites during meiosis. McKim KS. Cell, 2005 Dec 16. PMID 16360029
    5. Stromalin Constrains Memory Acquisition by Developmentally Limiting Synaptic Vesicle Pool Size. Phan A, et al. Neuron, 2019 Jan 2. PMID 30503644, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Memory suppression and the size of the synaptic vesicle pool is controlled genetically through Stromalin.
      Title: Stromalin Constrains Memory Acquisition by Developmentally Limiting Synaptic Vesicle Pool Size.
    2. Two cohesin subunits (SMC1 and SA) are essential for axon pruning.
      Title: piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning.
    3. Data show that Nipped-B is required for sister chromatid cohesion but that, opposite to the effect of Nipped-B, the stromalin/Scc3 component of Cohesin inhibits long-range activation of cut.
      Title: Drosophila nipped-B protein supports sister chromatid cohesion and opposes the stromalin/Scc3 cohesion factor to facilitate long-range activation of the cut gene.
    4. These results provide strong evidence that DSA1 and Drad21 are partners in a cohesin complex involved in the maintenance of sister chromatid arm and centromeric cohesion during mitosis in Drosophila.
      Title: Drosophila cohesins DSA1 and Drad21 persist and colocalize along the centromeric heterochromatin during mitosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic sister chromatid cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cohesin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitotic cohesin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stromalin 1
    Names
    CG3423-PA
    SA1-PA
    cohesin
    stromalin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6950421..6954586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057920.4 → NP_477268.2  stromalin 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477268.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18415, Q95RF8, Q9VM62
      Related
      FBpp0078977
      Conserved Domains (1) summary
      pfam08514
      Location:190 → 298
      STAG; STAG domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18415 O18415
    Q9VM62 Q9VM62

    Gene LinkOut

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