SdhB Succinate dehydrogenase, subunit B (iron-sulfur) [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SdhBprovided by FlyBase
Official Full Name: Succinate dehydrogenase, subunit B (iron-sulfur)provided by FlyBase
Primary source: FLYBASE:FBgn0014028
Locus tag: Dmel_CG3283
See related: AllianceGenome:FB:FBgn0014028
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3283; CII-SDHB; DHSB; Dmel\CG3283; Ip; SDH; SDH-B; SDH-Ip; SDH-IP; sdhB; Sdhb; SDHb
Summary: Predicted to enable iron-sulfur cluster binding activity; succinate dehydrogenase (quinone) activity; and ubiquinone binding activity. Involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Predicted to be active in mitochondrial membrane. Is expressed in several structures, including adult heart; anterior-posterior subdivision of organism; embryonic/larval midgut primordium; gut section; and larval muscle cell. Used to study mitochondrial complex II deficiency. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 42D3-42D4; 2-55 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (6807626..6809172)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (2695131..2696677)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

sdhB mutant is hypersensitive to oxygen and displays hallmarks of a progeroid syndrome
Title: Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 2 iron, 2 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables 3 iron, 4 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables 4 iron, 4 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables succinate dehydrogenase (quinone) activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquinone binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, succinate to ubiquinone	IDA Inferred from Direct Assay more info	PubMed
involved_in respiratory electron transport chain	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex II (succinate dehydrogenase)	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: succinate dehydrogenase, subunit B (iron-sulfur)

Names: CG3283-PA; COMPLEX II: iron-sulfur subunit; SdhB-PA; iron-sulfur protein subunit of succinate dehydrogenase; succinate dehydrogenase; succinate dehydrogenase B; succinate dehydrogenase Iron-sulfur; succinate dehydrogenase Iron-sulfur protein; succinate dehydrogenase [ubiquinone] iron-sulfur protein; succinate dehydrogenase complex subunit B; succinate dehydrogenase iron protein; succinate dehydrogenase subunit b

NP_477101.1

EC 1.-.-.-

EC 1.3.5.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

6807626..6809172

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057753.5 → NP_477101.1 succinate dehydrogenase, subunit B (iron-sulfur) [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477101.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P21914, Q9V9A0

Related

FBpp0085489

Conserved Domains (1) summary

PLN00129
Location:6 → 279

PLN00129; succinate dehydrogenase [ubiquinone] iron-sulfur subunit