Pur-alpha Purine-rich binding protein-alpha [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pur-alphaprovided by FlyBase
Official Full Name: Purine-rich binding protein-alphaprovided by FlyBase
Primary source: FLYBASE:FBgn0022361
Locus tag: Dmel_CG1507
See related: AllianceGenome:FB:FBgn0022361
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1507; Dmel\CG1507; dPur alpha; Pur alpha; Pur-a; pur-alpha; purA; Puralpha; PURalpha
Summary: Enables mRNA binding activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including adult head; female germline cell; and follicle cell. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 31. Orthologous to several human genes including PURB (purine rich element binding protein B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 102C5-102C5; 4-0 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (558016..567257)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (578642..587883)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The crystal structure reveals base-specific DNA recognition and offers a molecular explanation for the effect of point mutations in the 5q31.3 microdeletion syndrome.
Title: Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha.
The mRNA target spectrum of Pur-alpha is broader than previously anticipated, binding of trinucleotide repeat sequences in vitro and in vivo.
Title: Drosophila Pur-α binds to trinucleotide-repeat containing cellular RNAs and translocates to the early oocyte.
x-ray structure of residues 40 to 185 from Drosophila melanogaster Pur-alpha, which constitutes a major part of the core region
Title: X-ray structure of Pur-alpha reveals a Whirly-like fold and an unusual nucleic-acid binding surface.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 565178-565220 mobile_element_type = transposon:INE-1{}6116

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables purine-rich negative regulatory element binding	IBA Inferred from Biological aspect of Ancestor more info
enables purine-rich negative regulatory element binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Purine-rich binding protein-alpha

Names: CG1507-PA; CG1507-PB; CG1507-PC; CG1507-PD; CG1507-PE; CG1507-PF; CG1507-PG; Pur-alpha-PA; Pur-alpha-PB; Pur-alpha-PC; Pur-alpha-PD; Pur-alpha-PE; Pur-alpha-PF; Pur-alpha-PG

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004353.4 Reference assembly

Range

558016..567257

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079885.2 → NP_524624.1 Purine-rich binding protein-alpha, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524624.1

Status: REVIEWED

UniProtKB/TrEMBL

O16860, Q9V4D9

Related

FBpp0089038

Conserved Domains (1) summary

pfam04845
Location:41 → 254

PurA; PurA ssDNA and RNA-binding protein
NM_166767.2 → NP_726579.1 Purine-rich binding protein-alpha, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726579.1

Status: REVIEWED

UniProtKB/TrEMBL

O16860, Q95RR6

Related

FBpp0089039

Conserved Domains (1) summary

pfam04845
Location:41 → 253

PurA; PurA ssDNA and RNA-binding protein
NM_166769.2 → NP_726581.1 Purine-rich binding protein-alpha, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726581.1

Status: REVIEWED

UniProtKB/TrEMBL

O16860, Q8IMC4

Related

FBpp0089036

Conserved Domains (2) summary

smart00712
Location:28 → 90

PUR; DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria

pfam04845
Location:26 → 239

PurA; PurA ssDNA and RNA-binding protein
NM_001272134.1 → NP_001259063.1 Purine-rich binding protein-alpha, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259063.1

Status: REVIEWED

UniProtKB/TrEMBL

F3YDK4, O16860

Conserved Domains (2) summary

smart00712
Location:28 → 90

PUR; DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria

pfam04845
Location:26 → 238

PurA; PurA ssDNA and RNA-binding protein
NM_166768.2 → NP_726580.1 Purine-rich binding protein-alpha, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726580.1

Status: REVIEWED

UniProtKB/TrEMBL

O16860, Q95RR6

Related

FBpp0089037

Conserved Domains (1) summary

pfam04845
Location:41 → 253

PurA; PurA ssDNA and RNA-binding protein
NM_001272133.1 → NP_001259062.1 Purine-rich binding protein-alpha, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259062.1

Status: REVIEWED

UniProtKB/TrEMBL

O16860, Q9V4D9

Conserved Domains (1) summary

pfam04845
Location:41 → 254

PurA; PurA ssDNA and RNA-binding protein
NM_001272132.1 → NP_001259061.1 Purine-rich binding protein-alpha, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259061.1

Status: REVIEWED

UniProtKB/TrEMBL

O16860, Q95RR6

Conserved Domains (1) summary

pfam04845
Location:41 → 253

PurA; PurA ssDNA and RNA-binding protein