cta concertina [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ctaprovided by FlyBase
Official Full Name: concertinaprovided by FlyBase
Primary source: FLYBASE:FBgn0000384
Locus tag: Dmel_CG17678
See related: AllianceGenome:FB:FBgn0000384
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17678; CG40010; conc; Concertina; Cta; Dmel\CG17678; Galpha; Galpha12/13; Galpha[[12/13]]; GNA12/13; mat(2)cta; mat(2)fog
Summary: Predicted to enable D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including gastrulation; mesectoderm development; and regulation of embryonic development. Located in plasma membrane. Is expressed in several structures, including female germline cell; mesoderm; and organism subdivision. Orthologous to human GNA12 (G protein subunit alpha 12) and GNA13 (G protein subunit alpha 13). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (22981816..22992951)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (22874548..22885683)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila Fog/Cta and T48 pathways have overlapping and distinct contributions to mesoderm invagination.
Title: Drosophila Fog/Cta and T48 pathways have overlapping and distinct contributions to mesoderm invagination.
Data indicate that Ric-8 binds to Galpha12/13 subunit, Concertina (Cta) through an interface of conserved residues.
Title: Drosophila Ric-8 interacts with the Gα12/13 subunit, Concertina, during activation of the Folded gastrulation pathway.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Function	Evidence Code	Pubs
enables D5 dopamine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein activity	TAS Traceable Author Statement more info	PubMed
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase regulator activity	TAS Traceable Author Statement more info	PubMed
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in actin-mediated cell contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in apical constriction involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cytoskeleton polarity involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastrulation involving germ band extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesectoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of embryonic cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myosin II filament organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in brush border membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	TAS Traceable Author Statement more info	PubMed
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain