Gcna Germ cell nuclear acidic peptidase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gcnaprovided by FlyBase
Official Full Name: Germ cell nuclear acidic peptidaseprovided by FlyBase
Primary source: FLYBASE:FBgn0023515
Locus tag: Dmel_CG14814
See related: AllianceGenome:FB:FBgn0023515
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14814; Dmel\CG14814; EG:63B12.6
Summary: Enables DNA topoisomerase binding activity and MCM complex binding activity. Involved in positive regulation of DNA repair and protein-DNA covalent cross-linking repair. Located in P granule and chromosome. Is expressed in several structures, including CNS glial cell; germline cell; mesoderm; somatic muscle primordium; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 4. Orthologous to human GCNA (germ cell nuclear acidic peptidase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (1862009..1865835, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (1756042..1759868, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA topoisomerase binding	IDA Inferred from Direct Assay more info	PubMed
enables MCM complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-DNA covalent cross-linking repair	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain