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    Oli Olig family [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35066, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Oliprovided by FlyBase
    Official Full Name
    Olig familyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032651
    Locus tag
    Dmel_CG5545
    See related
    AllianceGenome:FB:FBgn0032651
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bHLHb23; CG5545; Dmel\CG5545; Doli; oli; Olig
    Summary
    Predicted to enable DNA-binding transcription factor activity and E-box binding activity. Involved in motor neuron axon guidance. Predicted to be active in nucleus. Is expressed in several structures, including CNS glial cell; central brain primordium; embryonic central brain neurons; ganglia; and somatic precursor cell. Orthologous to several human genes including BHLHE22 (basic helix-loop-helix family member e22). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Oli in Genome Data Viewer
    Location:
    36D1-36D1; 2-53 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17589184..17591267)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17589184..17591267)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45112 Neighboring gene long non-coding RNA:CR44411 Neighboring gene long non-coding RNA:CR44410 Neighboring gene uncharacterized protein Neighboring gene Synaptotagmin alpha Neighboring gene long non-coding RNA:CR44412

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Using Drosophila Motor Mutants to Teach Neurodevelopment in an Undergraduate Neurobiology Lab. Rothhaas S, et al. J Undergrad Neurosci Educ, 2020 Spring. PMID 32848517, Free PMC Article
    2. The Drosophila homeodomain transcription factor, Vnd, associates with a variety of co-factors, is extensively phosphorylated and forms multiple complexes in embryos. Zhang H, et al. FEBS J, 2008 Oct. PMID 18795949, Free PMC Article
    3. Regulatory Mechanisms of Metamorphic Neuronal Remodeling Revealed Through a Genome-Wide Modifier Screen in Drosophila melanogaster. Chen D, et al. Genetics, 2017 Jul. PMID 28476867, Free PMC Article
    4. A genomewide survey of basic helix-loop-helix factors in Drosophila. Moore AW, et al. Proc Natl Acad Sci U S A, 2000 Sep 12. PMID 10973473, Free PMC Article
    5. Regulation of locomotion and motoneuron trajectory selection and targeting by the Drosophila homolog of Olig family transcription factors. Oyallon J, et al. Dev Biol, 2012 Sep 15. PMID 22796650, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables E-box binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olig family
    Names
    CG5545-PA
    CG5545-PB
    CG5545-PC
    CG5545-PD
    Oli-PA
    Oli-PB
    Oli-PC
    Oli-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17589184..17591267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299088.1 → NP_001286017.1  olig family, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJC1
      Conserved Domains (1) summary
      cd18954
      Location:129 → 198
      bHLH_TS_bHLHe22_bHLHb5; basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 22 (bHLHe22) and similar proteins

    2. NM_078868.3 → NP_523592.1  olig family, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523592.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJC1
      Related
      FBpp0080539
      Conserved Domains (1) summary
      cd18954
      Location:129 → 198
      bHLH_TS_bHLHe22_bHLHb5; basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 22 (bHLHe22) and similar proteins

    3. NM_001201901.2 → NP_001188830.1  olig family, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188830.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJC1
      Conserved Domains (1) summary
      cd18954
      Location:129 → 198
      bHLH_TS_bHLHe22_bHLHb5; basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 22 (bHLHe22) and similar proteins

    4. NM_001201902.1 → NP_001188831.1  olig family, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188831.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJC1
      Conserved Domains (1) summary
      cd18954
      Location:129 → 198
      bHLH_TS_bHLHe22_bHLHb5; basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 22 (bHLHe22) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJC1 Q9VJC1

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