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    S-Lap1 Sperm-Leucylaminopeptidase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38986, updated on 9-Dec-2024

    Summary

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    Official Symbol
    S-Lap1provided by FlyBase
    Official Full Name
    Sperm-Leucylaminopeptidase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035915
    Locus tag
    Dmel_CG6372
    See related
    AllianceGenome:FB:FBgn0035915
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.89; bs33g03.y1; bs34e01.y1; CG6372; Dmel\CG6372; FBgn0035915; S-Lap 1; S-LAP 1
    Summary
    Predicted to enable manganese ion binding activity. Predicted to be involved in proteolysis. Located in major mitochondrial derivative. Is expressed in adult head; spermatogonium; spermatozoon; and testis. Orthologous to human LAP3 (leucine aminopeptidase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See S-Lap1 in Genome Data Viewer
    Location:
    66D8-66D8; 3-26 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8617235..8619474)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8610335..8612574)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sperm-Leucylaminopeptidase 2 Neighboring gene GTPase activating protein, SECIS-dependent read-through Neighboring gene Z band alternatively spliced PDZ-motif protein 66 Neighboring gene Cell division cycle 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recurrent gene co-amplification on Drosophila X and Y chromosomes. Ellison C, et al. PLoS Genet, 2019 Jul. PMID 31329593, Free PMC Article
    2. Expansion and functional diversification of a leucyl aminopeptidase family that encodes the major protein constituents of Drosophila sperm. Dorus S, et al. BMC Genomics, 2011 Apr 5. PMID 21466698, Free PMC Article
    3. Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance. Lu B, et al. Nat Neurosci, 2013 May. PMID 23525043
    4. Sperm-Leucylaminopeptidases are required for male fertility as structural components of mitochondrial paracrystalline material in Drosophila melanogaster sperm. Laurinyecz B, et al. PLoS Genet, 2019 Feb. PMID 30802236, Free PMC Article
    5. Differential microarray analysis of Drosophila mushroom body transcripts using chemical ablation. Kobayashi M, et al. Proc Natl Acad Sci U S A, 2006 Sep 26. PMID 16971484, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables metalloaminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in major mitochondrial derivative IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sperm-Leucylaminopeptidase 1
    Names
    CG6372-PA
    S-Lap1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8617235..8619474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139987.3 → NP_648244.1  Sperm-Leucylaminopeptidase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648244.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U24, Q9VSM6
      Related
      FBpp0076362
      Conserved Domains (2) summary
      PRK00913
      Location:44 → 542
      PRK00913; multifunctional aminopeptidase A; Provisional
      cd00433
      Location:55 → 541
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSM6 Q9VSM6

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