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    Exn Ephexin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39900, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Exnprovided by FlyBase
    Official Full Name
    Ephexinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261547
    Locus tag
    Dmel_CG42665
    See related
    AllianceGenome:FB:FBgn0261547
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH03693; CG14060; CG3799; CG42665; Dmel\CG42665; exn
    Old locus tag
    Dmel_CG14060; Dmel_CG3799
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in imaginal disc-derived leg morphogenesis; melanotic encapsulation of foreign target; and regulation of neurotransmitter secretion. Located in neuromuscular junction. Colocalizes with presynaptic membrane. Is expressed in several structures, including clypeo-labral primordium; embryonic epipharynx; epipharynx primordium; leg joint; and primary tracheal branch. Orthologous to several human genes including ARHGEF19 (Rho guanine nucleotide exchange factor 19). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Exn in Genome Data Viewer
    Location:
    73E1-73E2; 3-45 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16970013..16994388)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16963113..16987488)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 73D Neighboring gene Odorant-binding protein 73a Neighboring gene Oxoglutarate dehydrogenase Neighboring gene uncharacterized protein Neighboring gene mir-2500 stem loop Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An age-dependent change in the set point of synaptic homeostasis. Mahoney RE, et al. J Neurosci, 2014 Feb 5. PMID 24501352, Free PMC Article
    2. Eph Receptor Effector Ephexin Mediates Olfactory Dendrite Targeting in Drosophila. Sardana J, et al. Dev Neurobiol, 2018 Sep. PMID 30019861
    3. Notch signaling links interactions between the C/EBP homolog slow border cells and the GILZ homolog bunched during cell migration. Levine B, et al. Dev Biol, 2007 May 1. PMID 17383627
    4. A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels. Frank CA, et al. Neuron, 2009 Feb 26. PMID 19249276, Free PMC Article
    5. Rap1 coordinates cell-cell adhesion and cytoskeletal reorganization to drive collective cell migration in vivo. Rothenberg KE, et al. Curr Biol, 2023 Jul 10. PMID 37244252

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in melanotic encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ephexin
    Names
    CG42665-PA
    CG42665-PB
    CG42665-PC
    CG42665-PD
    CG42665-PE
    Exn-PA
    Exn-PB
    Exn-PC
    Exn-PD
    Exn-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16970013..16994388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104160.3 → NP_001097630.2  ephexin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097630.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAC5, Q9VVC6
      Conserved Domains (3) summary
      cd11793
      Location:1944 → 1998
      SH3_ephexin1_like; Src homology 3 domain of ephexin-1-like SH3 domain containing Rho guanine nucleotide exchange factors
      cd01221
      Location:1805 → 1931
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:1581 → 1763
      RhoGEF; RhoGEF domain

    2. NM_001202194.1 → NP_001189123.1  ephexin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189123.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAC5, Q9VVC6
      Conserved Domains (3) summary
      cd11793
      Location:1944 → 1998
      SH3_ephexin1_like; Src homology 3 domain of ephexin-1-like SH3 domain containing Rho guanine nucleotide exchange factors
      cd01221
      Location:1805 → 1931
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:1581 → 1763
      RhoGEF; RhoGEF domain

    3. NM_168705.2 → NP_730228.1  ephexin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730228.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y150
      Conserved Domains (4) summary
      cd11793
      Location:966 → 1020
      SH3_ephexin1_like; Src homology 3 domain of ephexin-1-like SH3 domain containing Rho guanine nucleotide exchange factors
      cd01221
      Location:827 → 953
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00169
      Location:829 → 947
      PH; PH domain
      pfam00621
      Location:603 → 785
      RhoGEF; RhoGEF domain

    4. NM_168706.2 → NP_730229.1  ephexin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730229.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y150
      Conserved Domains (4) summary
      cd11793
      Location:966 → 1020
      SH3_ephexin1_like; Src homology 3 domain of ephexin-1-like SH3 domain containing Rho guanine nucleotide exchange factors
      cd01221
      Location:827 → 953
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00169
      Location:829 → 947
      PH; PH domain
      pfam00621
      Location:603 → 785
      RhoGEF; RhoGEF domain

    5. NM_140685.5 → NP_648942.1  ephexin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648942.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y150
      Conserved Domains (4) summary
      cd11793
      Location:966 → 1020
      SH3_ephexin1_like; Src homology 3 domain of ephexin-1-like SH3 domain containing Rho guanine nucleotide exchange factors
      cd01221
      Location:827 → 953
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00169
      Location:829 → 947
      PH; PH domain
      pfam00621
      Location:603 → 785
      RhoGEF; RhoGEF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVC6 Q9VVC6
    Q9Y150 Q9Y150

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