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    morgue modifier of rpr and grim, ubiquitously expressed [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33648, updated on 9-Dec-2024

    Summary

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    Official Symbol
    morgueprovided by FlyBase
    Official Full Name
    modifier of rpr and grim, ubiquitously expressedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027609
    Locus tag
    Dmel_CG15437
    See related
    AllianceGenome:FB:FBgn0027609
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH02435; CG15437; Dmel\CG15437; FBXO18; Morgue
    Summary
    Enables K48-linked polyubiquitin modification-dependent protein binding activity. Involved in positive regulation of compound eye retinal cell apoptotic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including head; ovary; and pigment cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See morgue in Genome Data Viewer
    Location:
    24F2-24F2; 2-12 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4442870..4444680, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4442870..4444680, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Seminal fluid protein 24F Neighboring gene uncharacterized protein Neighboring gene Elongator complex protein 3 Neighboring gene Major Facilitator Superfamily Transporter 18 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The unique Morgue ubiquitination protein is conserved in a diverse but restricted set of invertebrates. Zhou Y, et al. Mol Biol Evol, 2009 Oct. PMID 19602541, Free PMC Article
    2. Drosophila morgue and the intersection between protein ubiquitination and programmed cell death. Schreader BA, et al. Apoptosis, 2003 Mar. PMID 12766473
    3. A subset of dorsal neurons modulates circadian behavior and light responses in Drosophila. Murad A, et al. Neuron, 2007 Mar 1. PMID 17329209, Free PMC Article
    4. Drosophila morgue associates with SkpA and polyubiquitin in vivo. Zhou Y, et al. PLoS One, 2013. PMID 24098672, Free PMC Article
    5. Drosophila morgue influences cell numbers and positions in the embryonic nervous system. Schreader BA, et al. Int J Dev Biol, 2010. PMID 21302253

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila morgue associates with SkpA and polyubiquitin in vivo.
      Title: Drosophila morgue associates with SkpA and polyubiquitin in vivo.
    2. study of normal developmental and physiological functions of morgue; study revealed Morgue localization in multiple cellular compartments; taken together, the diverse phenotypes observed and distribution patterns suggest pleiotropic functions for Morgue
      Title: Drosophila morgue influences cell numbers and positions in the embryonic nervous system.
    3. Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis.
      Title: Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis.
    4. Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1.
      Title: Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1.
    5. Drosophila morgue has a role in protein ubiquitination and programmed cell death
      Title: Drosophila morgue and the intersection between protein ubiquitination and programmed cell death.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables K48-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
    Inferred from Sequence Model
    more info
    		  
    involved_in positive regulation of compound eye retinal cell apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of compound eye retinal cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISM
    Inferred from Sequence Model
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    modifier of rpr and grim, ubiquitously expressed
    Names
    CG15437-PA
    morgue-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4442870..4444680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134989.3 → NP_608833.1  modifier of rpr and grim, ubiquitously expressed [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608833.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y165
      Related
      FBpp0077147
      Conserved Domains (4) summary
      COG5078
      Location:355 → 485
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:342 → 479
      UQ_con; Ubiquitin-conjugating enzyme
      pfam12406
      Location:92 → 190
      DUF3664; Surface protein
      pfam12937
      Location:234 → 275
      F-box-like; F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86NX0 Q86NX0
    Q9Y165 Q9Y165

    Gene LinkOut

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