CenG1A Centaurin gamma 1A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CenG1Aprovided by FlyBase
Official Full Name: Centaurin gamma 1Aprovided by FlyBase
Primary source: FLYBASE:FBgn0028509
Locus tag: Dmel_CG31811
See related: AllianceGenome:FB:FBgn0028509
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AGAP; BG:DS08220.1; cenG; ceng1A; cenG1a; cenG1A; CenG1a; CG16866; CG16867; CG31811; CG7982; Dmel\CG31811
Summary: Enables GTPase activator activity and GTPase activity. Involved in medium-term memory. Predicted to be located in membrane. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and sensory nervous system primordium. Used to study syndromic intellectual disability. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 34D6-34E2; 2-50 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (13835564..13898712)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (13835564..13898712)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CenG1A functions at both presynaptic and postsynaptic sites as a negative regulator of neurotransmitter release. Our study provided evidence for a key role of CenG1A in proper synaptic transmission at neuromuscular junctions.
Title: Downregulation of Centaurin gamma1A increases synaptic transmission at Drosophila larval neuromuscular junctions.
a novel role for Drosophila Ceng1A in regulating ecdysone signaling-dependent second to third instar larval transition.
Title: The PIKE homolog Centaurin gamma regulates developmental timing in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 13842517-13842580 mobile_element_type = transposon:jockey{}2307

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activator activity	ISM Inferred from Sequence Model more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in medium-term memory	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: centaurin gamma 1A

Names: CG31811-PA; CG31811-PB; CG31811-PC; CenG1A-PA; CenG1A-PB; CenG1A-PC; centaurin gamma; centaurin gamma-1A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

13835564..13898712

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165067.2 → NP_723849.1 centaurin gamma 1A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723849.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B7FNK5, I0C0M3, Q6IDF7, Q86P12, Q8MR30, Q95SF3, Q9NGC3, Q9NKE5, Q9VJV4, Q9VJV5, Q9VJV7

Related

FBpp0080123

Conserved Domains (9) summary

cd04103
Location:143 → 300

Centaurin_gamma; Centaurin gamma (CENTG) GTPase

smart00173
Location:144 → 295

RAS; Ras subfamily of RAS small GTPases

cd00204
Location:834 → 907

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01250
Location:451 → 686

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

pfam00169
Location:454 → 521

PH; PH domain

pfam01412
Location:702 → 818

ArfGap; Putative GTPase activating protein for Arf

pfam04592
Location:5 → 41

SelP_N; Selenoprotein P, N terminal region

pfam13857
Location:859 → 907

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:834 → 866

ANK; ANK repeat [structural motif]
NM_078838.3 → NP_523562.2 centaurin gamma 1A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523562.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NGC3

Related

FBpp0080124

Conserved Domains (8) summary

cd04103
Location:75 → 232

Centaurin_gamma; Centaurin gamma (CENTG) GTPase

smart00173
Location:76 → 227

RAS; Ras subfamily of RAS small GTPases

cd00204
Location:766 → 839

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01250
Location:383 → 618

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

pfam00169
Location:386 → 453

PH; PH domain

pfam01412
Location:634 → 750

ArfGap; Putative GTPase activating protein for Arf

pfam13857
Location:791 → 839

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:766 → 798

ANK; ANK repeat [structural motif]
NM_165068.2 → NP_723850.1 centaurin gamma 1A, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723850.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NGC3

Related

FBpp0080125

Conserved Domains (7) summary

cd00204
Location:602 → 675

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01250
Location:219 → 454

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

pfam00169
Location:222 → 289

PH; PH domain

pfam01412
Location:470 → 586

ArfGap; Putative GTPase activating protein for Arf

pfam13857
Location:627 → 675

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:602 → 634

ANK; ANK repeat [structural motif]

cl21455
Location:1 → 68

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases